KMT2E and ZCWPW1

		KMT2E	ZCWPW1
Description		lysine methyltransferase 2E (inactive)	zinc finger CW-type and PWWP domain containing 1
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GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Plasma Membrane Membrane Nuclear Body Nuclear Speck Protein-containing Complex Set3 Complex Rpd3L-Expanded Complex	Nucleus Chromosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone H3 Methyltransferase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity
	Biological Process	Neutrophil Mediated Immunity Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Gene Expression Erythrocyte Differentiation Epigenetic Regulation Of Gene Expression Neutrophil Activation Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Meiosis I Homologous Chromosome Pairing At Meiosis Spermatogenesis Cell Differentiation Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair
Pathways
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Brain morphology (MOSTest) ( 32665545) Family history of Alzheimer's disease ( 30617256) Hemoglobin levels ( 32327693) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: ALKBH4 ASH2L ATP13A1 CDCA8 CDK1 CRK CYP2C18 FIS1 IFT22 LAMTOR5 MAPRE2 NFE4 TRAPPC14 ZCWPW1	4 interacting genes: KMT2E L3MBTL3 MEOX2 VAC14
Entrez ID		55904	55063
HPRD ID		10528	15706
Ensembl ID		ENSG00000005483	ENSG00000078487
Uniprot IDs		Q8IZD2	A0A804HK41 Q9H0M4
PDB IDs		2LV9 4L58 5HT6	2E61 2RR4
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Midbody Regulation Of Metaphase Plate Congression Regulation Of Attachment Of Spindle Microtubules To Kinetochore Organelle Assembly Spindle Midzone Positive Regulation Of Chromosome Segregation Protein-containing Complex Pronuclear Fusion Spindle Cytoskeleton Organization DNA N6-methyladenine Demethylase Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Positive Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Mitotic DNA-templated DNA Replication Cellular Component Assembly Cyclin B1-CDK1 Complex Cilium Organization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Helper T Cell Diapedesis Positive Regulation Of Intracellular Signal Transduction Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Small GTPase Mediated Signal Transduction Linoleic Acid Epoxygenase Activity Epigenetic Regulation Of Gene Expression Positive Regulation Of ARF Protein Signal Transduction Cleavage Furrow Ingression Intracellular Protein Localization Response To Activity Regulation Of Organelle Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Chromosome Organization Cyclin-dependent Protein Kinase Activity Cerebellar Neuron Development Response To Flavonoid P-type Transmembrane Transporter Activity Spindle Assembly Regulation Of Schwann Cell Differentiation Response To Hydrogen Peroxide Microtubule-based Process Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Protein Localization To Nucleus Response To Toxic Substance	PAS Complex Set3 Complex Rpd3L-Expanded Complex Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Methylation-dependent Protein Binding Somite Specification Myeloid Cell Differentiation Presynaptic Endosome
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