TRAPPC14 and MEPCE

		TRAPPC14	MEPCE
Description		trafficking protein particle complex subunit 14	methylphosphate capping enzyme
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Spindle Cytoskeleton Plasma Membrane Midbody Vesicle Centriolar Satellite Mitotic Spindle TRAPPII Protein Complex	Nucleus 7SK SnRNP Ribonucleoprotein Complex
	Molecular Function	Protein Binding Alpha-tubulin Binding	RNA Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity SnRNA Binding 7SK SnRNA Binding RNA 5'-gamma-phosphate Methyltransferase Activity
	Biological Process	Cell Projection Organization Regulation Of Cell Population Proliferation Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II RNA Methylation SnRNA Metabolic Process Methylation SnRNA Modification Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of SnRNA Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: AGXT CYSRT1 KMT2E KRTAP6-1 MEPCE NBPF19 NOTCH2NLA TGM1 TMEM50A VWC2	6 interacting genes: ALKBH4 ERBB2 NFE4 RN7SK SMURF1 TRAPPC14
Entrez ID		55262	56257
HPRD ID		07716	07889
Ensembl ID		ENSG00000146826	ENSG00000146834
Uniprot IDs		B3KNS5 Q8WVR3	Q7L2J0
PDB IDs			5UNA 6DCB 6DCC 7SLP 7SLQ
Enriched GO Terms of Interacting Partners?		Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-serine-pyruvate Transaminase Activity Oxalic Acid Secretion Cornified Envelope Positive Regulation Of Cell Cycle Keratinization Cell Envelope Organization Set3 Complex Positive Regulation Of Cell Cycle G1/S Phase Transition Rpd3L-Expanded Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle RNA 5'-gamma-phosphate Methyltransferase Activity Glycine Biosynthetic Process Notch Signaling Pathway Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP SnRNA Modification Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle O-methyltransferase Activity Interstitial Matrix Oxalate Transport Glyoxylate Metabolic Process Extrinsic Component Of Postsynaptic Membrane Regulation Of Cell Cycle G1/S Phase Transition 7SK SnRNA Binding Positive Regulation Of Protein Localization To Cajal Body Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process SnRNA Binding	Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Positive Regulation Of Cell Growth ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Demethylase Activity DNA N6-methyladenine Demethylase Activity Midbody Broad Specificity Oxidative DNA Demethylase Activity Cleavage Furrow Ingression Protein Demethylase Activity Membrane Invagination Engulfment Of Target By Autophagosome 7SK SnRNP
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