PRKCI and PCM1

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		PRKCI	PCM1
Description		protein kinase C iota	pericentriolar material 1
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Brush Border Bicellular Tight Junction Cilium Microtubule Cytoskeleton Membrane Apical Plasma Membrane Cell Leading Edge Schmidt-Lanterman Incisure Intercellular Bridge Apical Part Of Cell Extracellular Exosome Tight Junction Schaffer Collateral - CA1 Synapse Glutamatergic Synapse PAR Polarity Complex	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Non-motile Cilium
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Protein Phosphorylation Protein Targeting To Membrane Cytoskeleton Organization Actin Filament Organization Positive Regulation Of Neuron Projection Development Vesicle-mediated Transport Cell Migration Establishment Of Cell Polarity Cellular Response To Insulin Stimulus Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Notch Signaling Pathway Positive Regulation Of D-glucose Import Secretion Golgi Vesicle Budding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Membrane Organization Cellular Response To Chemical Stress Response To Interleukin-1 Protein Localization To Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cell Projection Organization Cytoplasmic Microtubule Organization Protein Localization To Organelle Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Regulation Of Protein Complex Stability Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Protein-containing Complex Localization To Centriolar Satellite Non-motile Cilium Assembly
Pathways		Pre-NOTCH Transcription and Translation p75NTR recruits signalling complexes Tight junction interactions KEAP1-NFE2L2 pathway	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Tamoxifen Staurosporine Bisindolylmaleimide I Dequalinium Benzoyl peroxide Fostamatinib
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Microalbuminuria ( 31511532) Prostate cancer ( 25939597) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)	Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)
Interacting Genes		52 interacting genes: ADAP1 ANXA1 APP BAD CASK CASP8 CCNT1 CDC42 CDK7 CHUK CTBP1 FABP4 FCGR3A FRS2 FRS3 GAPDH HRAS IKBKG IL1RAP IRAK1 MAP2K1 MAP2K5 MAPT MARK4 MBP MEOX2 NACC1 NFKBIA PARD3 PARD6A PARD6B PARD6G PCM1 PDPK1 PIK3CA PNMA1 RAB2A RAB4A RAC1 RBM14 RHOQ SMG1 SMURF1 SQSTM1 SRC TSC22D1 TTR UBC USP20 VHL YWHAH YWHAZ	62 interacting genes: ABI1 ABI2 AKAP9 ALG13 APP BACE2 BBS4 BICD2 CASK CCHCR1 CDC42 CDK1 CEBPA CEP72 CYTH4 DDIT3 DDX23 DENND1A DPYSL2 DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FGF20 FXR2 GABARAP GOLGA2 GRN HAP1 ING5 INTS4 KAT5 KLC1 KLC4 KRT15 KRT19 KRT24 LARP4 LSM2 MCRS1 MORF4L1 NDUFA9 PCNT PDGFRL PPIE PRC1 PRKCI PRPF6 PXN RALBP1 RBM11 RBM5 RINT1 RPA2 TFIP11 TNFRSF10B TTC8 VPS26C WASHC3 ZNF830
Entrez ID		5584	5108
HPRD ID		02105	02624
Ensembl ID		ENSG00000163558	ENSG00000078674
Uniprot IDs		P41743	A0A4W8VX11 A0A5H1ZRS1 A2RUU9 B9EIS5 E9PGW9 Q15154
PDB IDs		1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8 5LI1 5LI9 5LIH 6ILZ 8R3X 8R3Y	6HYL 6HYM 7Q46
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Intracellular Signaling Cassette Positive Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cellular Localization Intracellular Signal Transduction Immune System Process PAR Polarity Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Response To Stress Regulation Of Gene Expression Positive Regulation Of Protein Localization Regulation Of Immune Response Plasma Membrane Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Projection Organization Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Organelle Organization Negative Regulation Of Programmed Cell Death Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Immune System Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Apoptotic Process Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Cell Projection Organization Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Regulation Of Primary Metabolic Process Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction	Cytoskeleton Organelle Organization Cytoskeleton Organization Microtubule-based Process Centrosome Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Cytosol Spliceosomal Complex Microtubule Cytoskeleton Organization Centriolar Satellite Regulation Of Supramolecular Fiber Organization Growth Cone Microtubule Organizing Center Organization Regulation Of Organelle Organization Catalytic Step 2 Spliceosome Cellular Component Assembly Regulation Of Cell Cycle Cellular Response To Stress Microtubule Intracellular Protein Localization Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization CHOP-C/EBP Complex Regulation Of Actin Filament Organization RNA Splicing Cytoplasm Cellular Localization Astrocyte Activation Involved In Immune Response Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Sensory Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex Epithelial Cell Differentiation Protein Transport Mitotic DNA Damage Checkpoint Signaling Regulation Of Cytoskeleton Organization RNA Splicing, Via Transesterification Reactions Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Mitotic Spindle Microtubule Nucleation MRNA Processing Golgi Disassembly Nuclear DNA Replication Organelle Disassembly
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