KDM3A and BTG3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		KDM3A	BTG3
Description		lysine demethylase 3A	BTG anti-proliferation factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Membrane	Nucleus Cytoplasm
	Molecular Function	Chromatin Binding Transcription Coregulator Activity Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3K9 Demethylase Activity Metal Ion Binding Nuclear Androgen Receptor Binding Dioxygenase Activity Histone H3K9me/H3K9me2 Demethylase Activity	Protein Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Spermatogenesis Spermatid Nucleus Elongation Hormone-mediated Signaling Pathway Regulation Of Gene Expression Cell Differentiation Androgen Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Formaldehyde Biosynthetic Process Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Leukemia Inhibitory Factor Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle
Pathways		HDMs demethylate histones NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Glomerular filtration rate in chronic kidney disease ( 26420894) Ovarian cancer ( 30557369)	Corpus callosum central volume ( 31530798) Feeling hurt ( 29500382)
Interacting Genes		7 interacting genes: BTG3 ETV2 H3C14 MRTFA MRTFB MYOCD RIPK2	76 interacting genes: ADNP2 AFF4 AGAP2 AHCYL1 AIP ATXN1 BANP CACNA1A CCDC13 CCT7 CLTC CLU CNOT7 CNOT8 CNTN4 COPS5 CREBZF CRYL1 DCLK2 DDX18 DIS3L DMAP1 DNAJC14 DNAJC7 DYNC1H1 EIF3C EIF3F EPRS1 GLUL HECTD2 HECTD4 HIVEP2 HSP90AA1 HSP90AB1 KCNQ2 KDM3A KIF3A MAPK8IP3 MORF4L1 MRPL38 MTM1 MYCBP2 NISCH NRBP1 OGT OSBPL8 OTOF PAK1 PAX6 PLA2G3 PLEKHB1 PPP2R5E PPP3CA PRKAR1A QARS1 RANBP9 RBL2 RNF10 RSPH1 SEC23IP SETDB1 SMG5 SPARCL1 SRPK2 SYNE1 TAF1 TAF6 TRIM32 TSC2 TSPAN7 USP8 WAPL WDFY3 XPC ZNF532 ZNF592
Entrez ID		55818	10950
HPRD ID		11054	10415
Ensembl ID		ENSG00000115548	ENSG00000154640
Uniprot IDs		Q9Y4C1	Q14201 Q6IAU3
PDB IDs
Enriched GO Terms of Interacting Partners?		Smooth Muscle Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Blood Vessel Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of Mesoderm Development Positive Regulation Of Macromolecule Biosynthetic Process Response To Interleukin-18 Regulation Of Cell Growth By Extracellular Stimulus Positive Regulation Of Biosynthetic Process Response To Interleukin-12 Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Urinary Bladder Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Mesoderm Development Positive Regulation Of T-helper 1 Cell Differentiation Toll-like Receptor 2 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway LIM Domain Binding Cellular Response To Peptidoglycan Immature T Cell Proliferation In Thymus Xenophagy Positive Regulation Of Immature T Cell Proliferation In Thymus Protein Linear Polyubiquitination Ventricular Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation Cardiac Ventricle Development Ductus Arteriosus Closure Regulation Of Phenotypic Switching Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Xenophagy Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Cytosol Cytoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Establishment Of Localization In Cell Regulation Of Macromolecule Biosynthetic Process Eukaryotic Translation Initiation Factor 3 Complex Organelle Organization Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process RNA Binding Cytoskeleton Organization Chaperone-mediated Protein Complex Assembly Protein Localization To Organelle Translation Initiation Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Unfolded Protein Binding Regulation Of Gene Expression Translation Intracellular Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Intracellular Protein Localization Disordered Domain Specific Binding Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Telomerase Holoenzyme Complex Assembly Negative Regulation Of Catabolic Process CCR4-NOT Core Complex Chromatin Organization 3'-5'-RNA Exonuclease Activity Positive Regulation Of Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding ATP-dependent Protein Folding Chaperone
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