BTG3 and CNOT7

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		BTG3	CNOT7
Description		BTG anti-proliferation factor 3	CCR4-NOT transcription complex subunit 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	P-body Nucleus Cytoplasm Cytosol Membrane Nuclear Body Nuclear Speck CCR4-NOT Complex CCR4-NOT Core Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity PiRNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Translation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Viral Genome Replication Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways			Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		Corpus callosum central volume ( 31530798) Feeling hurt ( 29500382)
Interacting Genes		76 interacting genes: ADNP2 AFF4 AGAP2 AHCYL1 AIP ATXN1 BANP CACNA1A CCDC13 CCT7 CLTC CLU CNOT7 CNOT8 CNTN4 COPS5 CREBZF CRYL1 DCLK2 DDX18 DIS3L DMAP1 DNAJC14 DNAJC7 DYNC1H1 EIF3C EIF3F EPRS1 GLUL HECTD2 HECTD4 HIVEP2 HSP90AA1 HSP90AB1 KCNQ2 KDM3A KIF3A MAPK8IP3 MORF4L1 MRPL38 MTM1 MYCBP2 NISCH NRBP1 OGT OSBPL8 OTOF PAK1 PAX6 PLA2G3 PLEKHB1 PPP2R5E PPP3CA PRKAR1A QARS1 RANBP9 RBL2 RNF10 RSPH1 SEC23IP SETDB1 SMG5 SPARCL1 SRPK2 SYNE1 TAF1 TAF6 TRIM32 TSC2 TSPAN7 USP8 WAPL WDFY3 XPC ZNF532 ZNF592	30 interacting genes: ALMS1 APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FBXO7 FHL3 FOXC2 HOXD4 IKBKG LSM3 MRFAP1L1 NMI OBI1 PABPC1 PIAS1 PSMC1 PSMC2 SCARA3 SH3GLB2 TCP11L1 TEX11 TOB1 TOB2 TSG101
Entrez ID		10950	29883
HPRD ID		10415	05370
Ensembl ID		ENSG00000154640	ENSG00000198791
Uniprot IDs		Q14201 Q6IAU3	Q96IQ6 Q9UIV1
PDB IDs			2D5R 4GMJ 7AX1 7VOI
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Establishment Of Localization In Cell Regulation Of Macromolecule Biosynthetic Process Eukaryotic Translation Initiation Factor 3 Complex Organelle Organization Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process RNA Binding Cytoskeleton Organization Chaperone-mediated Protein Complex Assembly Protein Localization To Organelle Translation Initiation Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Unfolded Protein Binding Regulation Of Gene Expression Translation Intracellular Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Intracellular Protein Localization Disordered Domain Specific Binding Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Telomerase Holoenzyme Complex Assembly Negative Regulation Of Catabolic Process CCR4-NOT Core Complex Chromatin Organization 3'-5'-RNA Exonuclease Activity Positive Regulation Of Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding ATP-dependent Protein Folding Chaperone	Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Cell Population Proliferation Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Proteolysis Histone Kinase Activity Proteasome-activating Activity Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Phorbol 13-acetate 12-myristate Proteasome Regulatory Particle, Base Subcomplex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm CCR4-NOT Complex
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