ENAH and ZYX

Number of citations of the paper that reports this interaction (PubMedID 10801818)
0

Data Source:
HPRD (in vitro, in vivo)

		ENAH	ZYX
Description		ENAH actin regulator	zyxin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium Filopodium Cell Projection Synapse Anchoring Junction Postsynapse GABA-ergic Synapse	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Phagocytic Vesicle Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Protein Domain Specific Binding WW Domain Binding	RNA Binding Protein Binding Metal Ion Binding
	Biological Process	Axon Guidance Actin Polymerization Or Depolymerization Actin Polymerization-dependent Cell Motility Postsynaptic Cytoskeleton Organization	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Stress Fiber Assembly Cellular Response To Type II Interferon
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors
Drugs			Artenimol
Diseases
GWAS		Delirium ( 29631748) Depression in smokers ( 30219690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Neuroticism ( 27067015) Obesity-related traits ( 23251661)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		28 interacting genes: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNAH14 DNMBP EVL FAT1 FYB1 GPHN HMGB1 KLHDC3 MAPK1 PFN1 PRPF40A RAC1 RAD51 ROBO4 SPTA1 TERF2IP TES VASP WAS XIRP1 YAP1 ZYX	36 interacting genes: ACTN1 ATXN1 BSPRY CASS4 CEBPA ENAH EVL HIPK3 IMP3 LAP3 LASP1 LATS1 LIN7A NEBL NEDD9 NME5 OPRM1 PDLIM5 PHF21A QRICH1 RABEPK RGS2 RPH3AL RTN4IP1 SIAH1 SREBF2 TES TUFT1 VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384 ZNF512B
Entrez ID		55740	7791
HPRD ID		12360	03592
Ensembl ID		ENSG00000154380	ENSG00000159840
Uniprot IDs		A0A097PIC4 A0A097PID1 A0A4D6J698 Q8N8S7	Q15942 Q96AF9
PDB IDs		2HO2 2IYB 2XQN 4MY6 5N91 5N9C 5N9P 5NAJ 5NBF 5NBX 5NC2 5NC7 5NCF 5NCG 5NCP 5ND0 5NDU 5NEG 6RCF 6RCJ 6RD2 6XVT 6XXR 7A5M 7AKI 7LXE 9C66
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Polymerization Or Depolymerization Supramolecular Fiber Organization Lamellipodium Cytoskeleton Proline-rich Region Binding Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Anchoring Junction Actin Filament-based Process Regulation Of Organelle Organization Positive Regulation Of Actin Filament Polymerization Focal Adhesion Positive Regulation Of Cytoskeleton Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Filament Polymerization Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Organelle Organization Actin Cytoskeleton Organization Regulation Of Cell Projection Assembly Regulation Of Cellular Component Size Regulation Of Ruffle Assembly Filopodium Actin-based Cell Projection Actin Cytoskeleton Positive Regulation Of Protein Polymerization Regulation Of Protein-containing Complex Assembly Regulation Of Lamellipodium Assembly Regulation Of Stress Fiber Assembly SCAR Complex SH3 Domain Binding Negative Regulation Of Cellular Component Organization Cytoplasm Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Postsynapse Cytoskeleton Organization Regulation Of Cell Motility Regulation Of Cell Shape Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Locomotion Cell Projection Morphogenesis Regulation Of Anatomical Structure Morphogenesis	Focal Adhesion Profilin Binding Anchoring Junction Actin Filament Organization Actin Binding Postsynapse Regulation Of Cellular Component Size Cytoplasm Stress Fiber Supramolecular Fiber Organization Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Protein Tyrosine Kinase Activity Actin Polymerization Or Depolymerization Platelet Activation Cytoskeletal Protein Binding Cytoskeleton Lamellipodium Regulation Of Cell Size
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