ENAH and ROBO4

Number of citations of the paper that reports this interaction (PubMedID 12941633)
0

Data Source:
HPRD (in vitro)

		ENAH	ROBO4
Description		ENAH actin regulator	roundabout guidance receptor 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium Filopodium Cell Projection Synapse Anchoring Junction Postsynapse GABA-ergic Synapse	Plasma Membrane External Side Of Plasma Membrane Membrane Axon Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Protein Domain Specific Binding WW Domain Binding	Protein Binding Signaling Receptor Activity Cell-cell Adhesion Mediator Activity
	Biological Process	Axon Guidance Actin Polymerization Or Depolymerization Actin Polymerization-dependent Cell Motility Postsynaptic Cytoskeleton Organization	Angiogenesis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Cell Differentiation Regulation Of Cell Migration Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Establishment Of Endothelial Barrier Dendrite Self-avoidance
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors
Drugs
Diseases
GWAS		Delirium ( 29631748) Depression in smokers ( 30219690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Neuroticism ( 27067015) Obesity-related traits ( 23251661)	Breast cancer (survival) ( 25890600) Venous thromboembolism ( 32232851)
Interacting Genes		28 interacting genes: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNAH14 DNMBP EVL FAT1 FYB1 GPHN HMGB1 KLHDC3 MAPK1 PFN1 PRPF40A RAC1 RAD51 ROBO4 SPTA1 TERF2IP TES VASP WAS XIRP1 YAP1 ZYX	5 interacting genes: CEP19 ENAH PPARG RXRA THRB
Entrez ID		55740	54538
HPRD ID		12360	09604
Ensembl ID		ENSG00000154380	ENSG00000154133
Uniprot IDs		A0A097PIC4 A0A097PID1 A0A4D6J698 Q8N8S7	B4DYV8 Q8WZ75
PDB IDs		2HO2 2IYB 2XQN 4MY6 5N91 5N9C 5N9P 5NAJ 5NBF 5NBX 5NC2 5NC7 5NCF 5NCG 5NCP 5ND0 5NDU 5NEG 6RCF 6RCJ 6RD2 6XVT 6XXR 7A5M 7AKI 7LXE 9C66
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Polymerization Or Depolymerization Supramolecular Fiber Organization Lamellipodium Cytoskeleton Proline-rich Region Binding Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Positive Regulation Of Supramolecular Fiber Organization Anchoring Junction Actin Filament-based Process Regulation Of Organelle Organization Positive Regulation Of Actin Filament Polymerization Focal Adhesion Positive Regulation Of Cytoskeleton Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Filament Polymerization Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Organelle Organization Actin Cytoskeleton Organization Regulation Of Cell Projection Assembly Regulation Of Cellular Component Size Regulation Of Ruffle Assembly Filopodium Actin-based Cell Projection Actin Cytoskeleton Positive Regulation Of Protein Polymerization Regulation Of Protein-containing Complex Assembly Regulation Of Lamellipodium Assembly Regulation Of Stress Fiber Assembly SCAR Complex SH3 Domain Binding Negative Regulation Of Cellular Component Organization Cytoplasm Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Postsynapse Cytoskeleton Organization Regulation Of Cell Motility Regulation Of Cell Shape Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Locomotion Cell Projection Morphogenesis Regulation Of Anatomical Structure Morphogenesis	Retinoic Acid Receptor Signaling Pathway Nuclear Receptor Activity MRNA Transcription By RNA Polymerase II Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway MRNA Transcription DNA Binding Domain Binding Positive Regulation Of Lipoprotein Transport Regulation Of Thyroid Hormone Receptor Signaling Pathway LBD Domain Binding Nuclear Receptor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Hormone-mediated Signaling Pathway Monocyte Differentiation WW Domain Binding Intracellular Receptor Signaling Pathway Positive Regulation Of Cholesterol Efflux Peptide Binding Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Transcription By RNA Polymerase II Transcription Coregulator Binding Regulation Of Cholesterol Efflux Enzyme Binding Regulation Of Cholesterol Transport DNA-templated Transcription Sequence-specific DNA Binding Positive Regulation Of Lipid Transport Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment MRNA Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Double-stranded DNA Binding Positive Regulation Of Adiponectin Secretion Retinal Cone Cell Apoptotic Process Female Courtship Behavior Regulation Of Lipid Transport Positive Regulation Of Lipid Metabolic Process Myeloid Leukocyte Differentiation Cell Maturation Vitamin D Response Element Binding Thyroid Hormone Receptor Signaling Pathway Prostaglandin Receptor Activity Negative Regulation Of Female Receptivity Vesicle Targeting, To, From Or Within Golgi Nucleobase-containing Compound Biosynthetic Process Receptor Complex Developmental Maturation Negative Regulation Of Mitochondrial Fission
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