RNF126 and PSMF1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		RNF126	PSMF1
Description		ring finger protein 126	proteasome inhibitor subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Proteasome Complex Cytoplasm Endoplasmic Reticulum Cytosol Proteasome Core Complex Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Proteasome Binding
	Biological Process	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Proteasome assembly
Drugs
Diseases
GWAS		Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Neonatal white matter microstructure ( 33009551)
Interacting Genes		42 interacting genes: ABCG2 AICDA BAG6 CENPP CSNK2B E2F1 EGFR FXN G0S2 HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SFN SNUPN TARDBP TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6	35 interacting genes: BEND7 CCDC85B CD2BP2 CRX CTBP2 DVL2 DVL3 GATA1 HOOK2 IKZF3 KHDRBS2 KHDRBS3 LDOC1 LNX1 LNX2 MAGEA11 MAGED1 MIEF2 NUDT21 PAK5 PDLIM7 QKI RAB33A RALYL RBFOX1 RBFOX2 RBMX RBPMS RHOXF2 RNF126 TENT5B TLE5 TRAF2 TRIM73 WWP2
Entrez ID		55658	9491
HPRD ID		11501	17919
Ensembl ID		ENSG00000070423	ENSG00000125818
Uniprot IDs		A8K0Q1 Q9BV68	A0A140VJT2 B4DXW9 Q5QPM7 Q92530
PDB IDs		2N9O 2N9P	2VT8 4OUH
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Ubiquitin Protein Ligase Binding Cytosol Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Macromolecule Catabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Damage Response Protein K11-linked Ubiquitination Nucleus Negative Regulation Of Metabolic Process Ubiquitin Binding Transferase Activity Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K63-linked Ubiquitination Catabolic Process Protein-containing Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Nucleoplasm Cellular Response To Stress Regulation Of Protein Modification Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Response To Stress Protein Catabolic Process Cytoplasm Negative Regulation Of Proteasomal Protein Catabolic Process	Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding MRNA Processing Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleic Acid Binding Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus RNA Processing Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Neuron Projection Arborization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process RNA Metabolic Process MRNA Stabilization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Neuron Projection Arborization Protein K63-linked Ubiquitination Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity RNA Splicing Nucleoplasm Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process SH3 Domain Binding Nucleic Acid Metabolic Process Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process TORC2 Complex Disassembly Internal N(7)-methylguanine-containing RNA Reader Activity Positive Regulation Of Pro-B Cell Differentiation
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