RNF126 and ABCG2

Number of citations of the paper that reports this interaction (PubMedID 32645369)
0

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		RNF126	ABCG2
Description		ring finger protein 126	ATP binding cassette subfamily G member 2 (JR blood group)
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Mitochondrion Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Mitochondrial Membrane Membrane Raft External Side Of Apical Plasma Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Urate Transmembrane Transporter Activity Biotin Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity Riboflavin Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Xenobiotic Transmembrane Transporter Activity Sphingolipid Transporter Activity Protein Dimerization Activity ABC-type Transporter Activity
	Biological Process	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Lipid Transport Organic Anion Transport Urate Transport Biotin Transport Sphingolipid Biosynthetic Process Riboflavin Transport Urate Metabolic Process Transmembrane Transport Transepithelial Transport Renal Urate Salt Excretion Export Across Plasma Membrane Transport Across Blood-brain Barrier Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Sphingolipid de novo biosynthesis Heme biosynthesis Heme degradation Abacavir transmembrane transport Iron uptake and transport Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Paracetamol ADME Ciprofloxacin ADME NFE2L2 regulating MDR associated enzymes
Drugs			Biricodar Avatrombopag Azvudine
Diseases
GWAS		Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)	Adult body size ( 32376654) Bitter beverage consumption ( 31046077) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Cardiovascular disease risk factors ( 21943158) Coffee consumption ( 31046077 31959922) Coffee consumption (cups per day) ( 31837886 25288136) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23064961) Glomerular filtration rate ( 29403010) Gout ( 32238385 25646370 23263486 31578528 33832965 21983786 30899057 27899376 29453348) Gout (combined type) ( 32238385) Gout (normal type) ( 32238385) Gout in chronic kidney disease ( 30181573) Gout vs asymptomatic hyperuricemia ( 33832965) Gout vs. Hyperuricemia ( 31289104 29453348) Hyperuricemia ( 29124443 28776340 29453348) Kidney stones ( 31729369) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Renal function-related traits (urate) ( 22797727) Renal overload gout ( 27899376 32238385) Renal underexcretion gout ( 27899376 32238385) Response to allopurinol in gout (change in serum uric acid levels) ( 30924126) Response to statins (LDL cholesterol change) ( 22331829) Serum metabolite levels ( 33031748) Serum urate levels ( 31784582) Serum urate levels in chronic kidney disease ( 30181573) Serum uric acid levels ( 24513273 29403010 21983786 32514006 30305239 26902266 30993211 29124443 31207883) Serum uric acid levels in response to allopurinol in gout ( 25676789) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Urate levels ( 31985003 20139978 23263486 31578528 18834626 20884846) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 29558500 22229870 19503597)
Interacting Genes		42 interacting genes: ABCG2 AICDA BAG6 CENPP CSNK2B E2F1 EGFR FXN G0S2 HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SFN SNUPN TARDBP TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6	1 interacting genes: RNF126
Entrez ID		55658	9429
HPRD ID		11501	04783
Ensembl ID		ENSG00000070423	ENSG00000118777
Uniprot IDs		A8K0Q1 Q9BV68	Q9UNQ0
PDB IDs		2N9O 2N9P	5NJ3 5NJG 6ETI 6FEQ 6FFC 6HBU 6HCO 6HIJ 6HZM 6VXF 6VXH 6VXI 6VXJ 7NEQ 7NEZ 7NFD 7OJ8 7OJH 7OJI 8BHT 8BI0 8P7W 8P8A 8P8J 8PXO 8PY4 8Q7B 8QCM 8U2C
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Ubiquitin Protein Ligase Binding Cytosol Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Macromolecule Catabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Damage Response Protein K11-linked Ubiquitination Nucleus Negative Regulation Of Metabolic Process Ubiquitin Binding Transferase Activity Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K63-linked Ubiquitination Catabolic Process Protein-containing Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Nucleoplasm Cellular Response To Stress Regulation Of Protein Modification Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Response To Stress Protein Catabolic Process Cytoplasm Negative Regulation Of Proteasomal Protein Catabolic Process	Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination DNA Strand Resection Involved In Replication Fork Processing Epidermal Growth Factor Receptor Binding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Negative Regulation Of ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Monoubiquitination Positive Regulation Of DNA Recombination Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein K63-linked Ubiquitination Regulation Of ERBB Signaling Pathway Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Retrograde Transport, Endosome To Golgi Protein K48-linked Ubiquitination Regulation Of DNA Recombination Cytosolic Transport Recombinational Repair Positive Regulation Of DNA Repair Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
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