PSMF1

Description		proteasome inhibitor subunit 1
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GO Annotations	Cellular Component	Proteasome Complex Cytoplasm Endoplasmic Reticulum Cytosol Proteasome Core Complex Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Proteasome Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Proteasome assembly
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Neonatal white matter microstructure ( 33009551)
Novel Interacting Genes		35 novel interacting genes: BEND7 CCDC85B CD2BP2 CRX CTBP2 DVL2 DVL3 GATA1 HOOK2 IKZF3 KHDRBS2 KHDRBS3 LDOC1 LNX1 LNX2 MAGEA11 MAGED1 MIEF2 NUDT21 PAK5 PDLIM7 QKI RAB33A RALYL RBFOX1 RBFOX2 RBMX RBPMS RHOXF2 RNF126 TENT5B TLE5 TRAF2 TRIM73 WWP2
Interacting Genes		35 interacting genes: BEND7 CCDC85B CD2BP2 CRX CTBP2 DVL2 DVL3 GATA1 HOOK2 IKZF3 KHDRBS2 KHDRBS3 LDOC1 LNX1 LNX2 MAGEA11 MAGED1 MIEF2 NUDT21 PAK5 PDLIM7 QKI RAB33A RALYL RBFOX1 RBFOX2 RBMX RBPMS RHOXF2 RNF126 TENT5B TLE5 TRAF2 TRIM73 WWP2
Entrez ID		9491
HPRD ID		17919
Ensembl ID		ENSG00000125818
Uniprot IDs		A0A140VJT2 B4DXW9 Q5QPM7 Q92530
PDB IDs		2VT8 4OUH
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding MRNA Processing Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleic Acid Binding Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus RNA Processing Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Neuron Projection Arborization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process RNA Metabolic Process MRNA Stabilization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Neuron Projection Arborization Protein K63-linked Ubiquitination Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity RNA Splicing Nucleoplasm Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process SH3 Domain Binding Nucleic Acid Metabolic Process Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process TORC2 Complex Disassembly Internal N(7)-methylguanine-containing RNA Reader Activity Positive Regulation Of Pro-B Cell Differentiation
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