MCM10 and MCM7

Number of citations of the paper that reports this interaction (PubMedID 28514442)
50

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MCM10	MCM7
Description		minichromosome maintenance 10 replication initiation factor	minichromosome maintenance complex component 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Replication Fork	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Membrane MCM Complex CMG Complex
	Molecular Function	DNA Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	DNA Replication DNA Replication Initiation DNA Damage Response Cell Population Proliferation	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Damage Response Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of DNA-templated DNA Replication Initiation Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Nicotine dependence symptom count ( 25555482) Survival time in esophageal squamous cell carcinoma ( 34185429)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		37 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A	80 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEBPA CEP68 CHEK1 COG6 CRLS1 CRYAA DBF4 DNAAF6 DUX4 DYNC1I1 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 LRR1 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RNF181 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM63 UBE3A UBQLN1 USHBP1
Entrez ID		55388	4176
HPRD ID		11297	01154
Ensembl ID		ENSG00000065328	ENSG00000166508
Uniprot IDs		Q7L590	A0A0S2Z4A5 C6EMX8 C9J8M6 P33993
PDB IDs			6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Origin Binding CMG Complex Regulation Of DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region MCM Complex Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process Regulation Of DNA-templated DNA Replication Initiation Cellular Response To Stress DNA Damage Response Origin Recognition Complex Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Negative Regulation Of Cell Cycle DNA Recombination G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Nucleus Regulation Of Cell Cycle Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Single-stranded DNA Binding Cell Division Cyclin D1-CDK6 Complex Cyclin D3-CDK6 Complex DNA Replication Preinitiation Complex Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Single-stranded DNA Helicase Activity Centrosome Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Metabolic Process Helicase Activity DNA Repair Protein Serine/threonine Kinase Binding Mitotic Cell Cycle Phase Transition Cytoplasm Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Cell Cycle Process Cell Cycle Phase Transition	DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Nucleoplasm Regulation Of DNA Replication Origin Recognition Complex Double-strand Break Repair Via Break-induced Replication Nucleus DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition CMG Complex MCM Complex Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Single-stranded DNA Binding Regulation Of Cell Cycle Process DNA Repair Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Cellular Response To Stress Recombinational Repair Mitotic DNA Integrity Checkpoint Signaling Chromosome Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle G1/S Phase Transition DNA Recombination Single-stranded DNA Helicase Activity Regulation Of Primary Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Transcription Factor TFIIK Complex Mitotic G2/M Transition Checkpoint CAK-ERCC2 Complex Mitotic DNA Replication Initiation Regulation Of Lipid Kinase Activity Macromolecule Metabolic Process
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