NUDT15 and SRD5A3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NUDT15	SRD5A3
Description		nudix hydrolase 15	steroid 5 alpha-reductase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Hydrolase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity 8-oxo-dGDP Phosphatase Activity Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity Polyprenol Reductase Activity Polyprenal Reductase Activity
	Biological Process	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Response To Stress Purine Deoxyribonucleoside Triphosphate Catabolic Process Xenobiotic Catabolic Process DNA Protection Nucleobase-containing Small Molecule Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Androgen Biosynthetic Process Polyprenol Catabolic Process Dolichyl Monophosphate Biosynthetic Process
Pathways		Phosphate bond hydrolysis by NUDT proteins Azathioprine ADME	Androgen biosynthesis Synthesis of dolichyl-phosphate Defective SRD5A3 causes SRD5A3-CDG, KHRZ
Drugs			Spironolactone
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CDADC1 FNDC3A GABARAPL2 MTRF1 SRD5A3 UTP14C	2 interacting genes: ADK NUDT15
Entrez ID		55270	79644
HPRD ID		14848	07825
Ensembl ID		ENSG00000136159	ENSG00000128039
Uniprot IDs		Q9NV35	A0A7P0TBH6 Q9H8P0
PDB IDs		5BON 5LPG 6T5J 7AOM 7AOP 7B63 7B64 7B65 7B66 7B67 7B7V 7NR6 7R0D
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Disassembly Translation Release Factor Activity, Codon Specific Mitochondrial Translational Termination Polyprenol Reductase Activity 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity 3-oxo-5-alpha-steroid 4-dehydrogenase Activity Polyprenol Catabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Polyprenal Reductase Activity DCMP Deaminase Activity Translation Release Factor Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Androgen Biosynthetic Process DNA Cytosine Deamination Translational Termination Cellular Response To Nitrogen Starvation Importin-alpha Family Protein Binding Cytidine Deaminase Activity DNA Deamination Phosphatidylethanolamine Binding Protein Localization To Endoplasmic Reticulum GABA Receptor Binding Sertoli Cell Development Dolichol-linked Oligosaccharide Biosynthetic Process Positive Regulation Of ATP-dependent Activity	Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Metabolic Process DATP Biosynthetic Process Adenosine Kinase Activity Deoxyadenosine Kinase Activity DAMP Salvage 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity 8-oxo-dGDP Phosphatase Activity DGTP Metabolic Process DGTP Catabolic Process 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity Purine Nucleotide Metabolic Process DATP Metabolic Process Purine Deoxyribonucleoside Triphosphate Catabolic Process GMP Salvage Nucleotide Metabolic Process Deoxyribonucleoside Triphosphate Catabolic Process Purine Ribonucleoside Salvage Purine-containing Compound Metabolic Process AMP Salvage Nucleoside Triphosphate Diphosphatase Activity DNA Protection Nucleoside Phosphate Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Nucleoside Triphosphate Catabolic Process Nucleoside Salvage AMP Biosynthetic Process GMP Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Carbohydrate Derivative Metabolic Process Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process AMP Metabolic Process Organophosphate Metabolic Process Purine Nucleoside Metabolic Process Purine Nucleotide Salvage Xenobiotic Catabolic Process GMP Metabolic Process Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process Purine-containing Compound Salvage Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Nucleoside Metabolic Process Phosphate-containing Compound Metabolic Process Small Molecule Metabolic Process Nucleoside Monophosphate Metabolic Process Purine Nucleotide Catabolic Process
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