USP40 and PMS2P1

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		USP40	PMS2P1
Description		ubiquitin specific peptidase 40	PMS1 homolog 2, mismatch repair system component pseudogene 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Mismatch Repair Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Kinase Activity Transferase Activity ATP Hydrolysis Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability	Mismatch Repair
Pathways
Drugs
Diseases
GWAS		Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)	Hemoglobin concentration ( 27863252) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA	2 interacting genes: LIG4 USP40
Entrez ID		55230	5379
HPRD ID		07166
Ensembl ID		ENSG00000085982	ENSG00000291178
Uniprot IDs		A0A7I2YQ75 C9JK14 Q9NVE5
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome	Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Nucleotide-excision Repair, DNA Gap Filling DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Double-strand Break Repair Via Classical Nonhomologous End Joining Lymphoid Progenitor Cell Differentiation Single Strand Break Repair AMP Binding Cellular Response To Lithium Ion Response To Lithium Ion V(D)J Recombination Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Response To X-ray Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Base-excision Repair Somatic Cell DNA Recombination T Cell Differentiation In Thymus Somatic Diversification Of Immunoglobulins Fibroblast Proliferation Response To Gamma Radiation Positive Regulation Of Fibroblast Proliferation Double-strand Break Repair Via Nonhomologous End Joining B Cell Activation Involved In Immune Response Somatic Stem Cell Population Maintenance Cellular Response To Ionizing Radiation Stem Cell Proliferation DNA Biosynthetic Process Regulation Of Fibroblast Proliferation Cysteine-type Deubiquitinase Activity Hematopoietic Progenitor Cell Differentiation Protein Deubiquitination Positive Regulation Of Chromosome Organization Neuron Apoptotic Process Stem Cell Population Maintenance Maintenance Of Cell Number Lymphocyte Activation Involved In Immune Response Neurogenesis Ligase Activity Protein Modification By Small Protein Removal
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