USP40 and IL11RA

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		USP40	IL11RA
Description		ubiquitin specific peptidase 40	interleukin 11 receptor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-11 Receptor Activity Protein Binding Interleukin-11 Binding
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability	Embryo Implantation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cell Differentiation Developmental Process Interleukin-11-mediated Signaling Pathway Head Development
Pathways			IL-6-type cytokine receptor ligand interactions
Drugs			Oprelvekin
Diseases
GWAS		Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)	CTACK levels ( 27989323)
Interacting Genes		45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA	5 interacting genes: CCL21 ELAVL2 IL11 OLFM4 USP40
Entrez ID		55230	3590
HPRD ID		07166	02965
Ensembl ID		ENSG00000085982	ENSG00000137070
Uniprot IDs		A0A7I2YQ75 C9JK14 Q9NVE5	Q14626
PDB IDs			6O4P 8DPS 8DPT 8DPU 8QY4
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome	Interleukin-11 Receptor Binding Dendritic Cell Dendrite Assembly Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Dendritic Cell Dendrite Assembly Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Tethering Or Rolling Chemokine (C-C Motif) Ligand 21 Signaling Pathway Cytokine Activity Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Cell-substrate Adhesion Interleukin-11-mediated Signaling Pathway Megakaryocyte Differentiation Regulation Of Complement-dependent Cytotoxicity Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Immunological Synapse Formation Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of Canonical NF-kappaB Signal Transduction Chemokine Receptor Binding Establishment Of T Cell Polarity Negative Regulation Of Cellular Extravasation Azurophil Granule Specific Granule Regulation Of Leukocyte Tethering Or Rolling Regulation Of T Cell Chemotaxis Cellular Response To Chemokine Dendritic Cell Chemotaxis Cytokine-mediated Signaling Pathway Extracellular Space Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Glycoprotein Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Lymphocyte Chemotaxis
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