USP40 and LDHB

Number of citations of the paper that reports this interaction (PubMedID 35605301)
0

Data Source:
BioGRID (two hybrid)

		USP40	LDHB
Description		ubiquitin specific peptidase 40	lactate dehydrogenase B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane Membrane Raft Extracellular Exosome Oxidoreductase Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Catalytic Activity Lactate Dehydrogenase Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Kinase Binding Identical Protein Binding NAD Binding
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability	Lactate Metabolic Process NAD+ Metabolic Process Carboxylic Acid Metabolic Process Pyruvate Catabolic Process
Pathways			Pyruvate metabolism
Drugs			NADH 4-Hydroxy-1,2,5-oxadiazole-3-carboxylic acid Oxamic Acid Stiripentol Artenimol
Diseases
GWAS		Bilirubin levels ( 21646302 31319653 31801373 32084209) Crohn's disease ( 22412388) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair greying ( 26926045)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		45 interacting genes: A2M ACSF2 ADH5 AHSA1 ALDOB APOM C1QA CLN8 COMMD6 DDB1 DDB2 EEF1A1 EEF1D EPB41L1 HCG11 HEBP2 HINT1 HSPA8 IL11RA ITGA6 LDHB LRP2 MT2A MTRNR2L1 NORAD OCLN OS9 PMS2P1 PSTK RACK1 RNF7 RPL30 RPS18 RPS20 RPS3A SLC12A1 SLC2A5 SRSF2 STT3A TCF25 TOMM20 TPT1 TRAPPC8 UBC VAPA	12 interacting genes: CEBPA CKS1B CKS2 MYCBP2 OGT PEX5 POT1 PTPRF SDCBP SUMO4 TERF1 USP40
Entrez ID		55230	3945
HPRD ID		07166	01026
Ensembl ID		ENSG00000085982	ENSG00000111716
Uniprot IDs		A0A7I2YQ75 C9JK14 Q9NVE5	A0A5F9ZHM4 P07195 Q5U077
PDB IDs			1I0Z 1T2F 7DBJ 7DBK 8QDE
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Translation Cytosolic Small Ribosomal Subunit Cytosolic Ribosome Ribosome Cytoplasmic Translation Translational Elongation Eukaryotic Translation Elongation Factor 1 Complex Small Ribosomal Subunit Cul4B-RING E3 Ubiquitin Ligase Complex Fructose Binding Cadherin Binding Protein Metabolic Process Host-mediated Activation Of Viral Genome Replication UV-damage Excision Repair Host-mediated Perturbation Of Viral Genome Replication Ribonucleoprotein Complex Insulin-like Growth Factor I Binding Response To Redox State Cul4A-RING E3 Ubiquitin Ligase Complex Import Across Plasma Membrane Structural Constituent Of Ribosome	Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Telomeric Loop Disassembly Telomere Capping G-rich Strand Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Nucleobase-containing Compound Metabolic Process Organelle Organization Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Modification Process Regulation Of Cellular Component Organization Chondroitin Sulfate Proteoglycan Binding Interleukin-5 Receptor Complex Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding SCF Ubiquitin Ligase Complex Circadian Regulation Of Gene Expression Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Response To Vitamin B2 C/EBP Complex Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Interleukin-5 Receptor Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly
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