FNBP1 and PDE6G

Number of citations of the paper that reports this interaction (PubMedID 14502124)
0

Data Source:
HPRD (two hybrid, in vitro)

		FNBP1	PDE6G
Description		formin binding protein 1	phosphodiesterase 6G
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Membrane Cytoplasmic Vesicle	Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity Enzyme Inhibitor Activity Protein Binding Hydrolase Activity Spectrin Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Endocytosis Signal Transduction	Visual Perception Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Pathways		Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RND2 GTPase cycle	Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway
Drugs			Sildenafil Tadalafil Vardenafil 3-isobutyl-1-methyl-7H-xanthine
Diseases			Retinitis pigmentosa (RP)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) ( 33208821) LDL peak particle diameter (total fat intake interaction) ( 26112879) Pediatric autoimmune diseases ( 26301688) Physiological dysregulation (Mahalanobis distance) ( 32235003)	Blond vs. brown/black hair color ( 30531825) High myopia ( 31816047) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: AGTR1 AKAP9 ARHGAP17 CBL CDC42 CEBPA DNM1 FASLG ITSN1 PDE6G RND2 SNX2 TNKS WASL	12 interacting genes: BHLHE40 DNM2 FNBP1 GNAO1 GRB2 GRK2 L3MBTL3 MAPK3 PRKAB2 SLC27A2 SRC TRIP10
Entrez ID		23048	5148
HPRD ID		10446	08914
Ensembl ID		ENSG00000187239	ENSG00000185527
Uniprot IDs		A0A8V8TQ35 A0A994J3U5 A0A994J3V8 B7ZL13 B7ZL14 H0Y7W6 Q96RU3	P18545
PDB IDs		2EFL	3JWR
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Regulation Of Plasma Membrane Organization Regulation Of Endocytosis Dendritic Spine Morphogenesis Regulation Of Postsynapse Organization Positive Regulation Of Filopodium Assembly Signal Transduction Positive Regulation Of Transport Endocytosis Dendritic Spine Organization Vesicle Budding From Membrane Protein Kinase Binding Lamellipodium Plasma Membrane Macrophage Differentiation Neuron Projection Organization Regulation Of Filopodium Assembly Postsynapse Organization Angiotensin Type I Receptor Activity Regulation Of Vesicle-mediated Transport Regulation Of Cytoskeleton Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Clathrin Coat Assembly Involved In Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Glutamatergic Synapse Regulation Of Transport Small GTPase-mediated Signal Transduction Bradykinin Receptor Binding Membrane Organization Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Cellular Response To Type II Interferon Import Into Cell Establishment Of Organelle Localization Cell Projection Morphogenesis Actin Filament Organization GBD Domain Binding Storage Vacuole Response To Vitamin B2 C/EBP Complex Vesicle Scission Clathrin-coated Pit Clathrin-dependent Synaptic Vesicle Endocytosis Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric	Import Into Cell Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Receptor Internalization ERBB Signaling Pathway Vesicle-mediated Transport Actin Cytoskeleton Organization Schwann Cell Development Regulation Of Early Endosome To Late Endosome Transport Contractile Actin Filament Bundle Assembly Stress Fiber Assembly ERBB2 Signaling Pathway Actin Filament-based Process Phagocytic Cup Ephrin Receptor Binding Receptor-mediated Endocytosis Cell Cortex Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Heart Contraction Signal Transduction Podosome Negative Regulation Of Immune Response Protein Domain Specific Binding T Cell Costimulation Phosphotyrosine Residue Binding Nucleotide Binding Peptidyl-tyrosine Phosphorylation Plasma Membrane Negative Regulation Of Relaxation Of Smooth Muscle Regulation Of Blood Circulation Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Guanyl-nucleotide Exchange Factor Adaptor Activity Cellular Response To Nutrient Levels Actin Filament Bundle Assembly Glial Cell Development TORC1 Signaling Actin Filament Bundle Organization Negative Regulation Of TORC1 Signaling Autophagy Clathrin-coated Pit Caveola Edg-2 Lysophosphatidic Acid Receptor Binding Negative Regulation Of Membrane Tubulation Vesicle Scission Mu-type Opioid Receptor Binding Insulin Receptor Signaling Pathway Grb2-EGFR Complex Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity
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