TLE3 and BMP3

		TLE3	BMP3
Description		TLE family member 3, transcriptional corepressor	bone morphogenetic protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Binding	Signaling Receptor Binding Cytokine Activity Growth Factor Activity BMP Receptor Binding
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis	Skeletal System Development Ossification Osteoblast Differentiation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-cell Signaling Cell Differentiation Negative Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 31562340 28552196 25282103) Hip circumference adjusted for BMI ( 34021172) L-selectin levels ( 25576479) Lumbar spine bone mineral density (integral) ( 27476799) Lung adenocarcinoma ( 28604730) Macular thickness ( 30535121) Male-pattern baldness ( 27182965) Monocyte percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Non-response to citalopram or escitalopram and depression ( 27622933) PR interval ( 32439900 30046033) Pulmonary function ( 23932459) Red blood cell count ( 32888494) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Schizophrenia ( 30285260 29483656 25056061) Serum total protein levels ( 29403010) Triglyceride levels ( 29403010 33339817) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) White blood cell count ( 32888494)	Cataracts ( 34127677) Corneal astigmatism ( 30306274) Height ( 18391951) Low myopia vs hyperopia ( 33830181) Myopia ( 27182965) Optic disc size ( 31809533) Pubertal anthropometrics ( 23449627) Refractive astigmatism ( 30306274) Refractive error ( 23396134 32231278) Retinal detachment or retinal break ( 31816047) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		17 interacting genes: APP CHERP CSTF2 FBXO7 FOXG1 H2AC1 H3C1 H4C1 HINFP KRTAP15-1 NDRG1 NOTCH1 PIN1 SIX1 SIX3 TCF4 USP47	5 interacting genes: COL4A1 COL4A2 KDM1A PRMT6 TGFB1
Entrez ID		7090	651
HPRD ID		02558	00208
Ensembl ID		ENSG00000140332	ENSG00000152785
Uniprot IDs		B3KUA2 H0YL70 Q04726 Q6PRX3	P12645
PDB IDs			2QCQ
Enriched GO Terms of Interacting Partners?		Protein Heterodimerization Activity Regulation Of Neuron Differentiation Nucleus Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Axon Midline Choice Point Recognition Regulation Of Neuroblast Proliferation Regulation Of Cell Cycle Process Axon Choice Point Recognition Regulation Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Regulation Of Cardioblast Proliferation Establishment Of Protein Localization To Organelle Mitogen-activated Protein Kinase Kinase Binding Apoptotic Process Nucleoplasm Negative Regulation Of Neuron Differentiation Cell Death Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Protein Targeting Structural Constituent Of Chromatin Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Neuron Differentiation Regulation Of Neural Precursor Cell Proliferation Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Notch Signaling Pathway Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cell Cycle Process Epithelial Cell Maturation Nucleosome Cellular Developmental Process Regulation Of Cell Differentiation Positive Regulation Of Neuroblast Proliferation Survivin Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of RNA Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Response To Calcium Ion Amylin Binding Cell Maturation Positive Regulation Of Toll Signaling Pathway	Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Extracellular Structure Organization Extracellular Matrix Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength Angiogenesis Regulation Of Neuroblast Proliferation Positive Regulation Of Stem Cell Proliferation Extracellular Matrix Collagen Trimer Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Ionizing Radiation Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Stem Cell Proliferation Cellular Response To Acetaldehyde Histone H2AR3 Methyltransferase Activity Basement Membrane Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Neural Precursor Cell Proliferation Extracellular Matrix Structural Constituent Regulation Of Multicellular Organismal Development Positive Regulation Of Primary MiRNA Processing Negative Regulation Of RNA Metabolic Process Embryonic Liver Development Regulation Of Epithelial To Mesenchymal Transition Mesenchymal Cell Differentiation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Multicellular Organismal Process Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Frontal Suture Morphogenesis Response To Ionizing Radiation Regulation Of DNA Recombination Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Regulation Of Cold-induced Thermogenesis Morphogenesis Of A Branching Epithelium Cell Maturation Morphogenesis Of A Branching Structure
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