MARCHF1 and FSTL5

		MARCHF1	FSTL5
Description		membrane associated ring-CH-type finger 1	follistatin like 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Trans-Golgi Network Membrane	Extracellular Region
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity MHC Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response Protein Ubiquitination	Cell Differentiation Regulation Of BMP Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847)	Adult body size ( 32376654) Bipolar disorder ( 31043756) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Chronotype ( 30696823) Colorectal cancer ( 25023989) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 20966902) HOMA-B (corrected for HOMA-IR) ( 30369944) Longevity ( 30294719) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Retinal detachment or retinal break ( 31816047) Retinitis pigmentosa ( 33514863) Serum immune biomarker levels ( 32066700) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		8 interacting genes: CDC34 FSTL5 HLA-DRA HLA-DRB1 INSR UBC UBE2D1 UBE2H	4 interacting genes: DDX60 DDX60L MARCHF1 TMA16
Entrez ID		55016	56884
HPRD ID		07940	10998
Ensembl ID		ENSG00000145416	ENSG00000168843
Uniprot IDs		A8K0Z6 D6RGC4 Q8TCQ1	Q8N475
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Myeloid Dendritic Cell Antigen Processing And Presentation Dendritic Cell Antigen Processing And Presentation Endocytic Vesicle Membrane Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Autolysosome Membrane Positive Regulation Of Memory T Cell Differentiation MHC Class II Receptor Activity Protein K48-linked Ubiquitination Regulation Of Memory T Cell Differentiation T Cell Receptor Binding Polysaccharide Binding Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Positive Regulation Of Regulatory T Cell Differentiation MHC Class II Protein Complex Binding Modification-dependent Protein Catabolic Process Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Endogenous Antigen Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Binding Regulation Of Regulatory T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Proteolysis Involved In Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Regulation Of T Cell Mediated Cytotoxicity Immunological Synapse Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Protein Polyubiquitination Regulation Of T-helper Cell Differentiation Transport Vesicle Membrane Positive Regulation Of Alpha-beta T Cell Differentiation ER To Golgi Transport Vesicle Membrane Protein Modification Process Post-translational Protein Modification Antigen Processing And Presentation Of Peptide Antigen Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of T Cell Mediated Immunity	Double-stranded RNA Binding Single-stranded RNA Binding RNA Helicase Activity Helicase Activity Positive Regulation Of MDA-5 Signaling Pathway MHC Protein Binding Defense Response To Virus Preribosome Binding ATP Hydrolysis Activity Positive Regulation Of RIG-I Signaling Pathway Response To Virus Regulation Of RIG-I Signaling Pathway
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