MARCHF1

Description		membrane associated ring-CH-type finger 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Trans-Golgi Network Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity MHC Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847)
Novel Interacting Genes		8 novel interacting genes: CDC34 FSTL5 HLA-DRA HLA-DRB1 INSR UBC UBE2D1 UBE2H
Interacting Genes		8 interacting genes: CDC34 FSTL5 HLA-DRA HLA-DRB1 INSR UBC UBE2D1 UBE2H
Entrez ID		55016
HPRD ID		07940
Ensembl ID		ENSG00000145416
Uniprot IDs		A8K0Z6 D6RGC4 Q8TCQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Myeloid Dendritic Cell Antigen Processing And Presentation Dendritic Cell Antigen Processing And Presentation Endocytic Vesicle Membrane Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Autolysosome Membrane Positive Regulation Of Memory T Cell Differentiation MHC Class II Receptor Activity Protein K48-linked Ubiquitination Regulation Of Memory T Cell Differentiation T Cell Receptor Binding Polysaccharide Binding Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Positive Regulation Of Regulatory T Cell Differentiation MHC Class II Protein Complex Binding Modification-dependent Protein Catabolic Process Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Endogenous Antigen Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Binding Regulation Of Regulatory T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Proteolysis Involved In Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Regulation Of T Cell Mediated Cytotoxicity Immunological Synapse Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Protein Polyubiquitination Regulation Of T-helper Cell Differentiation Transport Vesicle Membrane Positive Regulation Of Alpha-beta T Cell Differentiation ER To Golgi Transport Vesicle Membrane Protein Modification Process Post-translational Protein Modification Antigen Processing And Presentation Of Peptide Antigen Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of T Cell Mediated Immunity
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