FSTL5 and DDX60

		FSTL5	DDX60
Description		follistatin like 5	DExD/H-box helicase 60
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Cytoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Nucleotide Binding Nucleic Acid Binding Double-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Cell Differentiation Regulation Of BMP Signaling Pathway	Immune System Process Response To Virus Innate Immune Response Defense Response To Virus Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder ( 31043756) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Chronotype ( 30696823) Colorectal cancer ( 25023989) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 20966902) HOMA-B (corrected for HOMA-IR) ( 30369944) Longevity ( 30294719) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Retinal detachment or retinal break ( 31816047) Retinitis pigmentosa ( 33514863) Serum immune biomarker levels ( 32066700) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		4 interacting genes: DDX60 DDX60L MARCHF1 TMA16	3 interacting genes: FSTL5 RNF10 USP7
Entrez ID		56884	55601
HPRD ID		10998	07877
Ensembl ID		ENSG00000168843	ENSG00000137628
Uniprot IDs		Q8N475	A0A3G9HN97 A0A7P0T8Y0 Q6B0F7 Q8IY21 Q9H616 Q9NXV7
PDB IDs
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding Single-stranded RNA Binding RNA Helicase Activity Helicase Activity Positive Regulation Of MDA-5 Signaling Pathway MHC Protein Binding Defense Response To Virus Preribosome Binding ATP Hydrolysis Activity Positive Regulation Of RIG-I Signaling Pathway Response To Virus Regulation Of RIG-I Signaling Pathway	Regulation Of Establishment Of Protein Localization To Chromosome Monoubiquitinated Protein Deubiquitination Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Regulation Of Telomere Capping Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Gluconeogenesis K48-linked Deubiquitinase Activity Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Protein Ubiquitination Deubiquitinase Activity Protein Modification By Small Protein Conjugation
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