MIOS and SESN3

Number of citations of the paper that reports this interaction (PubMedID 25263562)
44

Data Source:
BioGRID (pull down)

		MIOS	SESN3
Description		meiosis regulator for oocyte development	sestrin 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cell Junction GATOR2 Complex	Nucleus Cytoplasm TORC2 Complex GATOR2 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor L-leucine Binding
	Biological Process	Protein-containing Complex Localization Cellular Response To Nutrient Levels Central Nervous System Myelin Formation Cellular Response To Amino Acid Starvation Oligodendrocyte Differentiation Oligodendrocyte Progenitor Proliferation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Positive Regulation Of Macroautophagy Response To Insulin Cellular Response To Amino Acid Starvation TORC2 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Amino acids regulate mTORC1	TP53 Regulates Metabolic Genes
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Diastolic blood pressure ( 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		3 interacting genes: NTAQ1 SESN1 SESN3	5 interacting genes: DSCR9 MIOS NPRL3 WDR24 WDR59
Entrez ID		54468	143686
HPRD ID		07898	09682
Ensembl ID		ENSG00000164654	ENSG00000149212
Uniprot IDs		Q9NXC5	P58005
PDB IDs		7UHY
Enriched GO Terms of Interacting Partners?		L-leucine Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Regulation Of Response To Reactive Oxygen Species GATOR2 Complex Cellular Response To Leucine Starvation Cellular Response To L-leucine Response To L-leucine Regulation Of Response To Oxidative Stress Cellular Response To Glucose Starvation Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Cellular Response To Amino Acid Stimulus Negative Regulation Of TOR Signaling Positive Regulation Of Macroautophagy Regulation Of TORC1 Signaling Response To Amino Acid Protein-N-terminal Glutamine Amidohydrolase Activity Regulation Of TOR Signaling Positive Regulation Of Autophagy Cellular Response To Starvation Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Autophagy TORC2 Complex Response To Nutrient Levels Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides TORC2 Signaling Oxidoreductase Activity Positive Regulation Of Catabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Insulin Receptor Signaling Pathway Cellular Oxidant Detoxification TOR Signaling Reactive Oxygen Species Metabolic Process Negative Regulation Of Signal Transduction Cellular Detoxification Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Response To Stress	Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling GATOR2 Complex Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of TOR Signaling Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Positive Regulation Of TORC1 Signaling Lysosomal Membrane Positive Regulation Of TOR Signaling Response To Nutrient Levels Lysosome Vacuolar Membrane Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Oligodendrocyte Progenitor Proliferation Cellular Response To Stress Seh1-associated Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy GATOR1 Complex Central Nervous System Myelin Formation Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Myelin Assembly Regulation Of Autophagy Response To Stress Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Aorta Morphogenesis Protein K6-linked Ubiquitination Ventricular Septum Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Catabolic Process Cellular_component Zinc Ion Binding Oligodendrocyte Differentiation Cardiac Septum Development Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation
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