MIOS and SESN1

Number of citations of the paper that reports this interaction (PubMedID 25263562)
44

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MIOS	SESN1
Description		meiosis regulator for oocyte development	sestrin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cell Junction GATOR2 Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol GATOR2 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor L-leucine Binding
	Biological Process	Protein-containing Complex Localization Cellular Response To Nutrient Levels Central Nervous System Myelin Formation Cellular Response To Amino Acid Starvation Oligodendrocyte Differentiation Oligodendrocyte Progenitor Proliferation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Positive Regulation Of Macroautophagy Negative Regulation Of Cell Growth Cellular Response To Amino Acid Starvation Cellular Response To Glucose Starvation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Amino acids regulate mTORC1	Amino acids regulate mTORC1 KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS			Asthma ( 32296059) Birth weight ( 31043758) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Prostate cancer ( 23535732)
Interacting Genes		3 interacting genes: NTAQ1 SESN1 SESN3	3 interacting genes: MIOS PRDX1 WDR24
Entrez ID		54468	27244
HPRD ID		07898	07310
Ensembl ID		ENSG00000164654	ENSG00000080546
Uniprot IDs		Q9NXC5	Q9Y6P5
PDB IDs		7UHY
Enriched GO Terms of Interacting Partners?		L-leucine Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Regulation Of Response To Reactive Oxygen Species GATOR2 Complex Cellular Response To Leucine Starvation Cellular Response To L-leucine Response To L-leucine Regulation Of Response To Oxidative Stress Cellular Response To Glucose Starvation Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Cellular Response To Amino Acid Stimulus Negative Regulation Of TOR Signaling Positive Regulation Of Macroautophagy Regulation Of TORC1 Signaling Response To Amino Acid Protein-N-terminal Glutamine Amidohydrolase Activity Regulation Of TOR Signaling Positive Regulation Of Autophagy Cellular Response To Starvation Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Autophagy TORC2 Complex Response To Nutrient Levels Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides TORC2 Signaling Oxidoreductase Activity Positive Regulation Of Catabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Insulin Receptor Signaling Pathway Cellular Oxidant Detoxification TOR Signaling Reactive Oxygen Species Metabolic Process Negative Regulation Of Signal Transduction Cellular Detoxification Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Response To Stress	GATOR2 Complex Positive Regulation Of TORC1 Signaling Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Oligodendrocyte Progenitor Proliferation Regulation Of TOR Signaling Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Central Nervous System Myelin Formation Lysosomal Membrane Regulation Of Intracellular Signal Transduction Removal Of Superoxide Radicals Erythrocyte Homeostasis Response To Nutrient Levels Lysosome Myelin Assembly Vacuolar Membrane Hydrogen Peroxide Catabolic Process Antioxidant Activity Protein K6-linked Ubiquitination Regulation Of Signal Transduction Peroxidase Activity Hydrogen Peroxide Metabolic Process Cell Population Proliferation Myeloid Cell Homeostasis Negative Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Stress-activated MAPK Cascade Cell Redox Homeostasis Natural Killer Cell Mediated Immunity Superoxide Metabolic Process Natural Killer Cell Mediated Cytotoxicity Regulation Of Cell Communication Regulation Of Stress-activated Protein Kinase Signaling Cascade Fibroblast Proliferation Regulation Of Signaling Oligodendrocyte Differentiation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Natural Killer Cell Activation Canonical NF-kappaB Signal Transduction Protein Localization To Lysosome
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