FBXW5 and KRTAP4-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FBXW5	KRTAP4-1
Description		F-box and WD repeat domain containing 5	keratin associated protein 4-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Keratinization
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Plateletcrit ( 32888494)
Interacting Genes		37 interacting genes: ADAMTSL4 CYP1A1 CYSRT1 EFEMP2 FAM168A FBLN2 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-12 KRTAP6-3 KRTAP9-3 KRTAP9-4 MDFI MID2 MTUS2 MYB NBPF19 NLK NOTCH2NLA PLEKHF2 S100B SASS6 SEC23B SKP1 TRIM27 TSC2 UBE2R2 VWC2	29 interacting genes: CATSPER1 CRCT1 CREB5 DHRS1 FBXW5 GNE HOXA1 IL10 KRTAP5-6 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1F LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE5A NECTIN3 NPDC1 NUFIP2 OTX1 PSMA1 SMCP VASN
Entrez ID		54461	85285
HPRD ID		10955	13940
Ensembl ID		ENSG00000159069	ENSG00000198443
Uniprot IDs		Q969U6	Q9BYQ7
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Interstitial Matrix Cytosol Structural Molecule Activity Supramolecular Fiber Organization Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription	Keratinization Epidermis Development Tissue Development
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