FBXW5 and KRTAP9-4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FBXW5	KRTAP9-4
Description		F-box and WD repeat domain containing 5	keratin associated protein 9-4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Keratinization
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Plateletcrit ( 32888494)
Interacting Genes		37 interacting genes: ADAMTSL4 CYP1A1 CYSRT1 EFEMP2 FAM168A FBLN2 KRT31 KRT34 KRT37 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-12 KRTAP6-3 KRTAP9-3 KRTAP9-4 MDFI MID2 MTUS2 MYB NBPF19 NLK NOTCH2NLA PLEKHF2 S100B SASS6 SEC23B SKP1 TRIM27 TSC2 UBE2R2 VWC2	29 interacting genes: ADAMTSL4 CATSPER1 CREB5 DHX57 DOCK2 FBXW5 HOXA1 KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE1B LCE3C LCE3E LCE4A MAPKBP1 NOTCH2NLA NTAQ1 NUFIP2 OTX1 PRKAB2 REL SMCP SPRY2 YIPF3
Entrez ID		54461	85280
HPRD ID		10955	13951
Ensembl ID		ENSG00000159069	ENSG00000241595
Uniprot IDs		Q969U6	Q9BYQ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Interstitial Matrix Cytosol Structural Molecule Activity Supramolecular Fiber Organization Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription	Intermediate Filament Keratin Filament Epidermis Development Keratinization Identical Protein Binding
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