CYCS and CYB5R3

Number of citations of the paper that reports this interaction (PubMedID 4403130)
0

Data Source:
HPRD (in vitro)

		CYCS	CYB5R3
Description		cytochrome c, somatic	cytochrome b5 reductase 3
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Apoptosome	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex
	Molecular Function	Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic Process Cellular Respiration Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process
Pathways		Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Pyroptosis TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity Cytoprotection by HMOX1	Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol	NADH Flavin adenine dinucleotide Copper
Diseases		Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)	Methemoglobinemia
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)	Initial pursuit acceleration ( 29064472)
Interacting Genes		22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2	85 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ARSA ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAS1 GAST GPR152 GRM2 HBG2 HSD17B13 L3MBTL2 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 RPS6KB1 SBF1 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C TUBGCP6 UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 XPNPEP3 YIPF4 ZDHHC15
Entrez ID		54205	1727
HPRD ID		00479	08942
Ensembl ID		ENSG00000172115	ENSG00000100243
Uniprot IDs		G4XXL9 P99999	P00387
PDB IDs		1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ 6XNK	1UMK 7THG 7TNV 7TSW 7W3O
Enriched GO Terms of Interacting Partners?		Electron Transport Chain Mitochondrial Outer Membrane Mitochondrion Neuron Apoptotic Process Generation Of Precursor Metabolites And Energy Mitochondrial Membrane Apoptosome Dendritic Cell Apoptotic Process Respiratory Electron Transport Chain Mitochondrial Membrane Organization Mitochondrion Organization Quinol-cytochrome-c Reductase Activity FAD Binding BH3 Domain Binding Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Epithelial Cell Apoptotic Process Leukocyte Apoptotic Process Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Bcl-2 Family Protein Complex Electron Transfer Activity Intrinsic Apoptotic Signaling Pathway Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Pore Complex Aerobic Electron Transport Chain Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Steroid Biosynthetic Process Mitochondrial Inner Membrane Response To Alkaloid Platelet Alpha Granule Membrane Aerobic Respiration Negative Regulation Of Anoikis Regulation Of Neuron Apoptotic Process Negative Regulation Of Autophagy Programmed Cell Death Involved In Cell Development Cellular Respiration Oxidative Phosphorylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Cytosol Positive Regulation Of Apoptotic Process Regulation Of Anoikis Ubiquitin Protein Ligase Binding Sterol Metabolic Process Protein Refolding Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport
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