CYB5R3 and XPNPEP3

		CYB5R3	XPNPEP3
Description		cytochrome b5 reductase 3	X-prolyl aminopeptidase 3
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding	Aminopeptidase Activity Protein Binding Peptidase Activity Metalloexopeptidase Activity Metallopeptidase Activity Hydrolase Activity Manganese Ion Binding Protein Homodimerization Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process	Glomerular Filtration Proteolysis Protein Processing
Pathways		Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		NADH Flavin adenine dinucleotide Copper
Diseases		Methemoglobinemia	Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Initial pursuit acceleration ( 29064472)	Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) C-reactive protein levels ( 30388399) Experiencing mood swings ( 29500382) Low density lipoprotein cholesterol levels ( 32154731) Refractive error ( 32231278) Schizophrenia ( 28991256)
Interacting Genes		85 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ARSA ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAS1 GAST GPR152 GRM2 HBG2 HSD17B13 L3MBTL2 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 RPS6KB1 SBF1 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C TUBGCP6 UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 XPNPEP3 YIPF4 ZDHHC15	2 interacting genes: CYB5R3 L3MBTL2
Entrez ID		1727	63929
HPRD ID		08942	10052
Ensembl ID		ENSG00000100243	ENSG00000196236
Uniprot IDs		P00387	A0A087X0Z2 Q9NQH7
PDB IDs		1UMK 7THG 7TNV 7TSW 7W3O	5X49
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport	Nitric-oxide Synthase Complex Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Nitrite Reductase (NO-forming) Activity Histone H4K20me1 Reader Activity Histone H4K20me2 Reader Activity Hemoglobin Complex Ectoderm Development Nitric Oxide Biosynthetic Process Sterol Biosynthetic Process Nitric Oxide Metabolic Process FAD Binding Reactive Nitrogen Species Metabolic Process Cholesterol Biosynthetic Process Blood Circulation Steroid Biosynthetic Process Azurophil Granule Lumen Promoter-specific Chromatin Binding Stem Cell Proliferation Lipid Droplet
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