CYB5R3 and LRCH4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYB5R3	LRCH4
Description		cytochrome b5 reductase 3	leucine rich repeats and calponin homology domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex	Plasma Membrane Membrane PML Body
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process	Membrane Raft Assembly Nervous System Development Positive Regulation Of Toll-like Receptor Signaling Pathway
Pathways		Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		NADH Flavin adenine dinucleotide Copper
Diseases		Methemoglobinemia
GWAS		Initial pursuit acceleration ( 29064472)	Brain morphology (MOSTest) ( 32665545) Macular thickness ( 30535121) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		85 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ARSA ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAS1 GAST GPR152 GRM2 HBG2 HSD17B13 L3MBTL2 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 RPS6KB1 SBF1 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C TUBGCP6 UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 XPNPEP3 YIPF4 ZDHHC15	17 interacting genes: CA8 CYB5R3 ELOVL7 HSD17B11 KASH5 KRT40 KRTAP10-7 KRTAP10-8 MDFI NOTCH2NLA PRKAR2B RBBP6 RETREG3 RNASEK RTN4 SIN3A SPOP
Entrez ID		1727	4034
HPRD ID		08942	10062
Ensembl ID		ENSG00000100243	ENSG00000077454
Uniprot IDs		P00387	B4DYF8 H7C5D9 O75427
PDB IDs		1UMK 7THG 7TNV 7TSW 7W3O
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport	Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Keratin Filament
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