POLE3 and SMARCA5

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (pull down, affinity chromatography technology, biochemical)

		POLE3	SMARCA5
Description		DNA polymerase epsilon 3, accessory subunit	SNF2 related chromatin remodeling ATPase 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Pericentric Heterochromatin Epsilon DNA Polymerase Complex CHRAC ATAC Complex	Chromatin Condensed Chromosome Fibrillar Center Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Pericentric Heterochromatin Nucleolus CHRAC NURF Complex ACF Complex ISWI-type Complex RSF Complex Site Of Double-strand Break Nuclear Replication Fork WICH Complex NoRC Complex CERF Complex B-WICH Complex
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nucleosome Binding Histone Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity Histone Octamer Slider Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA-templated DNA Replication Leading Strand Elongation Regulation Of DNA Replication Nucleosome Assembly Chromatin Remodeling DNA Damage Response Heterochromatin Formation DNA Biosynthetic Process	RDNA Heterochromatin Formation Regulation Of DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Transcription By RNA Polymerase I Heterochromatin Formation Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Antiviral Innate Immune Response Negative Regulation Of Mitotic Chromosome Condensation Cellular Response To Leukemia Inhibitory Factor
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Deposition of new CENPA-containing nucleosomes at the centromere
Drugs		Cladribine	Beta-D-Glucose 4-Deoxy-Alpha-D-Glucose
Diseases
GWAS			Appendicular lean mass ( 33097823) Height ( 31562340) Malaria ( 31844061)
Interacting Genes		13 interacting genes: ALAD APP ASTN2 CHRAC1 CST3 DR1 DRAP1 EIF4G2 GSN POLE4 SMARCA5 TNC TRIM32	20 interacting genes: BAZ1A BAZ1B BAZ2A CDT1 CHRAC1 CREB1 CTNNB1 DNMT3B GSK3A H3-3A H3C1 H4C16 HDAC2 MAF POLE3 PTEN RAD21 RSF1 SATB1 USP7
Entrez ID		54107	8467
HPRD ID		06274	04538
Ensembl ID		ENSG00000148229	ENSG00000153147
Uniprot IDs		Q9NRF9	O60264
PDB IDs			6NE3 8V4Y 8V6V 8V7L 9E1L 9E1M 9E1N 9E1O 9E1P 9E1Q 9E1R 9E1U 9E1V 9E1W 9E1X
Enriched GO Terms of Interacting Partners?		Negative Cofactor 2 Complex Protein Heterodimerization Activity CHRAC Regulation Of Proteolysis Epsilon DNA Polymerase Complex Protein-containing Complex Assembly Protein-containing Complex Organization Response To Peptide Response To Cytokine ATAC Complex Response To Lead Ion Ficolin-1-rich Granule Lumen Regulation Of Protein Catabolic Process Regulation Of Macromolecule Metabolic Process DNA-directed DNA Polymerase Activity TBP-class Protein Binding Amyloid Fibril Formation Pericentric Heterochromatin Regulation Of Primary Metabolic Process Porphobilinogen Synthase Activity Proteasome Core Complex Binding Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Mechanical Stimulus Regulation Of Cell Cycle Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Protein-DNA Complex Assembly RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Perisynaptic Extracellular Matrix Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production DNA-templated DNA Replication Cellular Component Assembly Regulation Of Growth Axon Development Regulation Of Cellular Component Organization Response To Vitamin Acetylcholine Receptor Activator Activity Immune Response Innate Immune Response	Chromatin Remodeling Chromatin Organization Protein-DNA Complex Assembly Nucleosome Assembly Nucleosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process CHRAC Negative Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Pericentric Heterochromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Chromatin Negative Regulation Of Gene Expression, Epigenetic Macromolecule Metabolic Process Cellular Component Assembly Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Fungiform Papilla Formation Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Chromosome Organization Negative Regulation Of Chromosome Condensation Regulation Of DNA Replication Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Hair Follicle Placode Formation Epsilon DNA Polymerase Complex Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression DNA Replication DNA-templated DNA Replication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process
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