POLE3 and ALAD

		POLE3	ALAD
Description		DNA polymerase epsilon 3, accessory subunit	aminolevulinate dehydratase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Pericentric Heterochromatin Epsilon DNA Polymerase Complex CHRAC ATAC Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	Catalytic Activity Porphobilinogen Synthase Activity Zinc Ion Binding Lyase Activity Identical Protein Binding Metal Ion Binding Proteasome Core Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA-templated DNA Replication Leading Strand Elongation Regulation Of DNA Replication Nucleosome Assembly Chromatin Remodeling DNA Damage Response Heterochromatin Formation DNA Biosynthetic Process	Response To Hypoxia Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Oxidative Stress Response To Nutrient Response To Xenobiotic Stimulus Response To Herbicide Response To Toxic Substance Response To Hormone Response To Metal Ion Response To Iron Ion Response To Zinc Ion Response To Aluminum Ion Response To Ionizing Radiation Response To Vitamin B1 Response To Selenium Ion Response To Lead Ion Response To Activity Response To Nutrient Levels Response To Cobalt Ion Response To Lipopolysaccharide Tetrapyrrole Biosynthetic Process Response To Vitamin E Response To Vitamin Response To Amino Acid Response To Ethanol Response To Arsenic-containing Substance Response To Cadmium Ion Response To Mercury Ion Heme O Biosynthetic Process Protein Homooligomerization Response To Glucocorticoid Response To Methylmercury Response To Platinum Ion Response To Fatty Acid Cellular Response To Lead Ion Cellular Response To Interleukin-4 Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Heme biosynthesis Neutrophil degranulation
Drugs		Cladribine	Aminolevulinic acid Delta-Amino Valeric Acid Laevulinic Acid 4-Oxosebacic Acid Porphobilinogen 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid 4,7-Dioxosebacic Acid 5-hydroxyvaleric acid
Diseases			Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS			High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lead levels in blood ( 25820613) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		13 interacting genes: ALAD APP ASTN2 CHRAC1 CST3 DR1 DRAP1 EIF4G2 GSN POLE4 SMARCA5 TNC TRIM32	2 interacting genes: HUNK POLE3
Entrez ID		54107	210
HPRD ID		06274	00504
Ensembl ID		ENSG00000148229	ENSG00000148218
Uniprot IDs		Q9NRF9	A0A140VJL9 B7Z3I9 P13716 Q6ZMU0
PDB IDs			1E51 1PV8 5HMS 5HNR
Enriched GO Terms of Interacting Partners?		Negative Cofactor 2 Complex Protein Heterodimerization Activity CHRAC Regulation Of Proteolysis Epsilon DNA Polymerase Complex Protein-containing Complex Assembly Protein-containing Complex Organization Response To Peptide Response To Cytokine ATAC Complex Response To Lead Ion Ficolin-1-rich Granule Lumen Regulation Of Protein Catabolic Process Regulation Of Macromolecule Metabolic Process DNA-directed DNA Polymerase Activity TBP-class Protein Binding Amyloid Fibril Formation Pericentric Heterochromatin Regulation Of Primary Metabolic Process Porphobilinogen Synthase Activity Proteasome Core Complex Binding Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Mechanical Stimulus Regulation Of Cell Cycle Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Protein-DNA Complex Assembly RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Perisynaptic Extracellular Matrix Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production DNA-templated DNA Replication Cellular Component Assembly Regulation Of Growth Axon Development Regulation Of Cellular Component Organization Response To Vitamin Acetylcholine Receptor Activator Activity Immune Response Innate Immune Response	CHRAC Epsilon DNA Polymerase Complex Leading Strand Elongation DNA Strand Elongation Involved In DNA Replication ATAC Complex DNA-directed DNA Polymerase Activity DNA Strand Elongation Pericentric Heterochromatin
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