POLE3 and ASTN2

		POLE3	ASTN2
Description		DNA polymerase epsilon 3, accessory subunit	astrotactin 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Pericentric Heterochromatin Epsilon DNA Polymerase Complex CHRAC ATAC Complex	Cytoplasm Endosome Early Endosome Late Endosome Cell Cortex Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Perikaryon Cell Pole
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	Calcium Ion Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA-templated DNA Replication Leading Strand Elongation Regulation Of DNA Replication Nucleosome Assembly Chromatin Remodeling DNA Damage Response Heterochromatin Formation DNA Biosynthetic Process	Neuron Migration Neuron Cell-cell Adhesion Protein Transport Protein Localization To Cell Surface Establishment Of Body Hair Planar Orientation Negative Regulation Of Protein Localization To Cell Surface
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine
Diseases
GWAS			Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder and schizophrenia ( 20889312) Body mass index ( 28448500 28892062) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Caudal middle frontal gyrus volume ( 31530798) Chronic obstructive pulmonary disease ( 30804561) Dentate gyrus granule cell layer volume ( 30279459) Depression ( 29700475) Drug-induced liver injury (isoniazid-containing anti-tuberculosis drugs) ( 33135175) Economic and political preferences (fairness) ( 22566634) Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling guilty ( 29500382) FEV1 ( 30804560) Glomerular filtration rate (creatinine) ( 28452372) Glucose homeostasis traits ( 25524916) Headache ( 29397368) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip shape (DXA scan) ( 30320955) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 22504421) Idiopathic osteonecrosis of the femoral head ( 28000841) Immune response to anthrax vaccine ( 22658931) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lung function (FEV1/FVC) ( 28166213 26635082 30804560) Medication use (antimigraine preparations) ( 31015401) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 27322543 23793025) Multisite chronic pain ( 33830993 31194737) Nonunion in individuals with fractures ( 30680360) Obesity-related traits ( 23251661) Osteoarthritis (hip) ( 30374069 30664745) Peak expiratory flow ( 30804560) PR interval ( 32439900) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment ( 20195266) Shoulder impingement or rotator cuff tear ( 33482370) Subiculum volume ( 30279459) Survival in pancreatic cancer ( 28470677) Total hippocampal volume ( 30279459) Transverse temporal cortex volume ( 31530798) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: ALAD APP ASTN2 CHRAC1 CST3 DR1 DRAP1 EIF4G2 GSN POLE4 SMARCA5 TNC TRIM32	5 interacting genes: CHRM5 DYRK1A POLE3 TNC TRIM32
Entrez ID		54107	23245
HPRD ID		06274	12498
Ensembl ID		ENSG00000148229	ENSG00000148219
Uniprot IDs		Q9NRF9	B3KN99 B7ZKP4 B7ZKP5 O75129 X6R5P2
PDB IDs			5J67 5J68 5J69
Enriched GO Terms of Interacting Partners?		Negative Cofactor 2 Complex Protein Heterodimerization Activity CHRAC Regulation Of Proteolysis Epsilon DNA Polymerase Complex Protein-containing Complex Assembly Protein-containing Complex Organization Response To Peptide Response To Cytokine ATAC Complex Response To Lead Ion Ficolin-1-rich Granule Lumen Regulation Of Protein Catabolic Process Regulation Of Macromolecule Metabolic Process DNA-directed DNA Polymerase Activity TBP-class Protein Binding Amyloid Fibril Formation Pericentric Heterochromatin Regulation Of Primary Metabolic Process Porphobilinogen Synthase Activity Proteasome Core Complex Binding Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Mechanical Stimulus Regulation Of Cell Cycle Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Protein-DNA Complex Assembly RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Perisynaptic Extracellular Matrix Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production DNA-templated DNA Replication Cellular Component Assembly Regulation Of Growth Axon Development Regulation Of Cellular Component Organization Response To Vitamin Acetylcholine Receptor Activator Activity Immune Response Innate Immune Response	Cellular Response To Stress Histone H3T45 Kinase Activity Axon Development Perisynaptic Extracellular Matrix Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Extracellular Matrix Of Synaptic Cleft Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Protein Localization To Phagocytic Vesicle Tenascin Complex Bud Outgrowth Involved In Lung Branching Syndecan Binding Actin Modification Striated Muscle Myosin Thick Filament CHRAC Leading Strand Elongation G Protein-coupled Acetylcholine Receptor Activity Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Cellular Response To Prostaglandin D Stimulus Cytosolic Ciliogenesis Epsilon DNA Polymerase Complex Peripheral Nervous System Axon Regeneration Interstitial Matrix Free Ubiquitin Chain Polymerization Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Gastric Acid Secretion Cellular Response To Nutrient Levels Regulation Of Heterochromatin Formation Mesenchymal-epithelial Cell Signaling Transcription Coactivator Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Tat Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Neurofilament Cellular Response To Vitamin D Branch Elongation Of An Epithelium Negative Regulation Of Microtubule Polymerization DNA Strand Elongation Involved In DNA Replication ATAC Complex Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Cell Growth Axis Elongation
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