PNOC and OPRL1

Number of citations of the paper that reports this interaction (PubMedID 10692489)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		PNOC	OPRL1
Description		prepronociceptin	opioid related nociceptin receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Dendrite Neuronal Cell Body Axon Terminus Synaptic Membrane	Plasma Membrane Membrane Cytoplasmic Vesicle Neuron Projection Synaptic Membrane
	Molecular Function	Opioid Peptide Activity Neuropeptide Hormone Activity Protein Binding Opioid Receptor Binding Receptor Ligand Activity	Nociceptin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Neuropeptide Binding
	Biological Process	Signal Transduction Neuropeptide Signaling Pathway Chemical Synaptic Transmission Neuron-neuron Synaptic Transmission Female Pregnancy Sensory Perception Sensory Perception Of Pain	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Neuron-neuron Synaptic Transmission Sensory Perception Sensory Perception Of Pain Calcium-mediated Signaling G Protein-coupled Opioid Receptor Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		Body mass index ( 28892062) Daytime nap ( 33568662) Metabolite levels ( 23823483)	A body shape index ( 34021172) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: FBXO7 OPRL1	10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2
Entrez ID		5368	4987
HPRD ID		03268	03971
Ensembl ID		ENSG00000168081	ENSG00000125510
Uniprot IDs		Q13519	A0A5F9ZI64 P41146 Q8IXB0
PDB IDs		8F7X	4EA3 5DHG 5DHH 8F7X
Enriched GO Terms of Interacting Partners?		Nociceptin Receptor Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core G Protein-coupled Opioid Receptor Activity Neuron-neuron Synaptic Transmission G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Neuropeptide Binding Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting To Mitochondrion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway G Protein-coupled Peptide Receptor Activity Sensory Perception Of Pain	Regulation Of Copper Ion Transmembrane Transport TAP Binding Neuropeptide Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of NMDA Receptor Activity Cellular Response To Morphine Morphine Receptor Activity Sensory Perception Of Pain Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Opioid Receptor Binding Opioid Peptide Activity G Protein-coupled Receptor Catabolic Process Regulation Of Transcytosis Compact Myelin Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport Positive Regulation Of Oligodendrocyte Apoptotic Process Receptor Ligand Activity
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