OPRL1 and PNOC

Number of citations of the paper that reports this interaction (PubMedID 10692489)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		OPRL1	PNOC
Description		opioid related nociceptin receptor 1	prepronociceptin
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Neuron Projection Synaptic Membrane	Extracellular Region Plasma Membrane Dendrite Neuronal Cell Body Axon Terminus Synaptic Membrane
	Molecular Function	Nociceptin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Neuropeptide Binding	Opioid Peptide Activity Neuropeptide Hormone Activity Protein Binding Opioid Receptor Binding Receptor Ligand Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Neuron-neuron Synaptic Transmission Sensory Perception Sensory Perception Of Pain Calcium-mediated Signaling G Protein-coupled Opioid Receptor Signaling Pathway	Signal Transduction Neuropeptide Signaling Pathway Chemical Synaptic Transmission Neuron-neuron Synaptic Transmission Female Pregnancy Sensory Perception Sensory Perception Of Pain
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		A body shape index ( 34021172) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Body mass index ( 28892062) Daytime nap ( 33568662) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2	2 interacting genes: FBXO7 OPRL1
Entrez ID		4987	5368
HPRD ID		03971	03268
Ensembl ID		ENSG00000125510	ENSG00000168081
Uniprot IDs		A0A5F9ZI64 P41146 Q8IXB0	Q13519
PDB IDs		4EA3 5DHG 5DHH 8F7X	8F7X
Enriched GO Terms of Interacting Partners?		Regulation Of Copper Ion Transmembrane Transport TAP Binding Neuropeptide Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of NMDA Receptor Activity Cellular Response To Morphine Morphine Receptor Activity Sensory Perception Of Pain Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Opioid Receptor Binding Opioid Peptide Activity G Protein-coupled Receptor Catabolic Process Regulation Of Transcytosis Compact Myelin Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport Positive Regulation Of Oligodendrocyte Apoptotic Process Receptor Ligand Activity	Nociceptin Receptor Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core G Protein-coupled Opioid Receptor Activity Neuron-neuron Synaptic Transmission G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Neuropeptide Binding Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting To Mitochondrion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway G Protein-coupled Peptide Receptor Activity Sensory Perception Of Pain
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?