OPRL1 and DNAJC30

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		OPRL1	DNAJC30
Description		opioid related nociceptin receptor 1	DnaJ heat shock protein family (Hsp40) member C30
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GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Neuron Projection Synaptic Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Nociceptin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Neuropeptide Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Neuron-neuron Synaptic Transmission Sensory Perception Sensory Perception Of Pain Calcium-mediated Signaling G Protein-coupled Opioid Receptor Signaling Pathway	ATP Biosynthetic Process Brain Development Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		A body shape index ( 34021172) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Malaria ( 31844061)
Interacting Genes		10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2	30 interacting genes: AQP6 BEST2 CALN1 CREB3 EBP EXOSC6 FAM209A FATE1 FBXO7 GPX8 JAGN1 KASH5 LMNA LRRC25 MGST2 MRM1 MSMO1 OPRL1 PEX12 REEP4 RNF170 S100B SIGLEC12 SLC10A4 SLC35H1 SLC51A SLC71A2 TMEM31 TMEM52B TMEM86B
Entrez ID		4987	84277
HPRD ID		03971	10303
Ensembl ID		ENSG00000125510	ENSG00000176410
Uniprot IDs		A0A5F9ZI64 P41146 Q8IXB0	B3KSU4 Q96LL9
PDB IDs		4EA3 5DHG 5DHH 8F7X	2YUA
Enriched GO Terms of Interacting Partners?		Regulation Of Copper Ion Transmembrane Transport TAP Binding Neuropeptide Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of NMDA Receptor Activity Cellular Response To Morphine Morphine Receptor Activity Sensory Perception Of Pain Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Opioid Receptor Binding Opioid Peptide Activity G Protein-coupled Receptor Catabolic Process Regulation Of Transcytosis Compact Myelin Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport Positive Regulation Of Oligodendrocyte Apoptotic Process Receptor Ligand Activity	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum
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