PLAGL1 and DRC3

		PLAGL1	DRC3
Description		PLAG1 like zinc finger 1	dynein regulatory complex subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Nuclear Body	Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases		Transient neonatal diabetes mellitus (TNDM)
GWAS		Anti-saccade response ( 29064472) Eosinophil percentage of granulocytes ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density x serum urate levels interaction ( 34046847) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Peanut allergy (maternal genetic effects) ( 29489655) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		13 interacting genes: CREBBP DAXX DRC3 EP300 KAT2B PIAS2 PML SMAD3 SUMO1 TLE5 TP53 UBE2I ZBTB14	12 interacting genes: EIF3E ELAC2 FUNDC2 GID4 MFHAS1 PLAGL1 SMCR8 SOD2 SPECC1 ZNF250 ZNF287 ZNF624
Entrez ID		5325	83450
HPRD ID		16010	13181
Ensembl ID		ENSG00000118495	ENSG00000171962
Uniprot IDs		A1YLA1 A1YLA2 Q9UM63	B3KSC6 Q9H069
PDB IDs			8J07
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Stabilization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Transcription Coactivator Binding Protein Sumoylation N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Stability P53 Binding Acetyltransferase Activity SUMO Transferase Activity Histone H3K27 Acetyltransferase Activity Regulation Of Transcription By RNA Polymerase II Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Rhythmic Process Intracellular Signaling Cassette Histone H3K18 Acetyltransferase Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Gene Expression Response To Hypoxia Protein Acetylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Transcription Coregulator Activity Regulation Of Macromolecule Biosynthetic Process Response To Decreased Oxygen Levels Apoptotic Signaling Pathway Regulation Of Primary Metabolic Process Response To Oxygen Levels Chromatin Remodeling Cellular Response To Stress
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