GSKIP and EVL

		GSKIP	EVL
Description		GSK3B interacting protein	Enah/Vasp-like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium Cell Projection
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Beta-catenin Binding Kinase Regulator Activity Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Protein Homotetramerization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Supramolecular Fiber Organization
Pathways			Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases
GWAS		Conotruncal heart defects (inherited effects) ( 28468790)	Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		3 interacting genes: EVL EXT2 PEX19	46 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP ATG2B BDKRB1 BEGAIN C14orf132 CEBPA CFTR CKB CRKL DNMBP ENAH F11R FXR1 FXR2 FYB1 FYN GSKIP HCK HTT KRT17 KRT34 LRP1B LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		51527	51466
HPRD ID		16601	10942
Ensembl ID		ENSG00000100744	ENSG00000196405
Uniprot IDs		Q9P0R6	A0A024R6K5 A0A2D1PGY7 Q9UI08
PDB IDs		1SGO
Enriched GO Terms of Interacting Partners?		N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity UDP-N-acetylglucosamine Transferase Complex Heparan Sulfate N-acetylglucosaminyltransferase Activity Negative Regulation Of Lipid Binding Peroxisome Membrane Biogenesis Peroxisome Membrane Class-1 Targeting Sequence Binding Peroxisome Membrane Targeting Sequence Binding Heparin Proteoglycan Biosynthetic Process Endochondral Bone Morphogenesis Protein Import Into Peroxisome Membrane Membrane Biogenesis Negative Regulation Of Ruffle Assembly Protein Targeting To Peroxisome Protein Carrier Chaperone Profilin Binding Peroxisome Fission Heparin Proteoglycan Metabolic Process Heparan Sulfate Proteoglycan Biosynthetic Process Acetylglucosaminyltransferase Activity Sulfation Catalytic Complex Heart Contraction Glycosaminoglycan Biosynthetic Process Animal Organ Morphogenesis Regulation Of Biological Quality Glucuronosyltransferase Activity Polysaccharide Biosynthetic Process Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Negative Regulation Of Epithelial Cell Migration Peroxisome Organization Multicellular Organismal-level Water Homeostasis Heparan Sulfate Proteoglycan Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ruffle Assembly Heart Process Bone Morphogenesis Fluid Transport Sodium Ion Homeostasis Response To Fibroblast Growth Factor Mesoderm Formation Glycosaminoglycan Metabolic Process Positive Regulation Of Actin Filament Polymerization Vasodilation Brush Border Membrane Positive Regulation Of Stress Fiber Assembly Chondrocyte Differentiation Formation Of Primary Germ Layer Proteoglycan Biosynthetic Process	Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Actin Filament-based Process Cytoskeleton Actin Filament Organization Fc-gamma Receptor Signaling Pathway Actin Cytoskeleton Organization Supramolecular Fiber Organization Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Cell Migration Cell Motility Actin Polymerization Or Depolymerization Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Ephrin Receptor Binding Regulation Of Cell Projection Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Component Organization Regulation Of Cell Shape Negative Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Response To Xenobiotic Stimulus Cell Junction Anatomical Structure Morphogenesis Cell Projection Organization Cytoplasm Cellular Response To Transforming Growth Factor Beta Stimulus Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein Tyrosine Kinase Activity Regulation Of Developmental Process Synapse Protein-containing Complex Regulation Of Actin Cytoskeleton Organization Leukocyte Migration Regulation Of Cell Projection Assembly Immune Response-activating Signaling Pathway
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