GSKIP and EXT2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GSKIP	EXT2
Description		GSK3B interacting protein	exostosin glycosyltransferase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Golgi Membrane Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane UDP-N-acetylglucosamine Transferase Complex Extracellular Exosome Catalytic Complex
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Beta-catenin Binding Kinase Regulator Activity Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding	Protein Binding Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Polysaccharide Biosynthetic Process Ossification Mesoderm Formation Chondrocyte Differentiation Glycosaminoglycan Biosynthetic Process Protein Glycosylation Protein N-linked Glycosylation Regulation Of Blood Pressure Gene Expression Heparan Sulfate Proteoglycan Biosynthetic Process Heparin Proteoglycan Biosynthetic Process Fluid Transport Vasodilation Cellular Response To Fibroblast Growth Factor Stimulus Multicellular Organismal-level Water Homeostasis Sulfation Sodium Ion Homeostasis Heart Contraction Endochondral Bone Morphogenesis
Pathways			HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Drugs
Diseases			Multiple exostoses Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Conotruncal heart defects (inherited effects) ( 28468790)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: EVL EXT2 PEX19	10 interacting genes: ANXA7 CDKN1A EXT1 GALNT5 GSKIP PFDN1 SMN1 TK1 TRAP1 UBC
Entrez ID		51527	2132
HPRD ID		16601	00599
Ensembl ID		ENSG00000100744	ENSG00000151348
Uniprot IDs		Q9P0R6	Q93063
PDB IDs		1SGO	7SCH 7SCJ 7SCK 7UQX 7UQY 7ZAY
Enriched GO Terms of Interacting Partners?		N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity UDP-N-acetylglucosamine Transferase Complex Heparan Sulfate N-acetylglucosaminyltransferase Activity Negative Regulation Of Lipid Binding Peroxisome Membrane Biogenesis Peroxisome Membrane Class-1 Targeting Sequence Binding Peroxisome Membrane Targeting Sequence Binding Heparin Proteoglycan Biosynthetic Process Endochondral Bone Morphogenesis Protein Import Into Peroxisome Membrane Membrane Biogenesis Negative Regulation Of Ruffle Assembly Protein Targeting To Peroxisome Protein Carrier Chaperone Profilin Binding Peroxisome Fission Heparin Proteoglycan Metabolic Process Heparan Sulfate Proteoglycan Biosynthetic Process Acetylglucosaminyltransferase Activity Sulfation Catalytic Complex Heart Contraction Glycosaminoglycan Biosynthetic Process Animal Organ Morphogenesis Regulation Of Biological Quality Glucuronosyltransferase Activity Polysaccharide Biosynthetic Process Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Negative Regulation Of Epithelial Cell Migration Peroxisome Organization Multicellular Organismal-level Water Homeostasis Heparan Sulfate Proteoglycan Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ruffle Assembly Heart Process Bone Morphogenesis Fluid Transport Sodium Ion Homeostasis Response To Fibroblast Growth Factor Mesoderm Formation Glycosaminoglycan Metabolic Process Positive Regulation Of Actin Filament Polymerization Vasodilation Brush Border Membrane Positive Regulation Of Stress Fiber Assembly Chondrocyte Differentiation Formation Of Primary Germ Layer Proteoglycan Biosynthetic Process	Glycosaminoglycan Biosynthetic Process Negative Regulation Of Kinase Activity Protein Kinase Inhibitor Activity PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Wound Healing Negative Regulation Of Protein Kinase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Lymphocyte Adhesion To Endothelial Cell Of High Endothelial Venule Glycosaminoglycan Metabolic Process Mesenchymal Cell Differentiation Involved In Bone Development Stomach Development Perichondral Bone Morphogenesis Sweat Gland Development Smoothened Signaling Pathway Involved In Lung Development Heparan Sulfate N-acetylglucosaminyltransferase Activity Thymidine Kinase Activity Translational Attenuation Epithelial Cell Differentiation Negative Regulation Of Protein Phosphorylation Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity DNA Synthesis Involved In Mitotic DNA Replication Kinase Regulator Activity Protein Kinase Binding Protein O-linked Glycosylation Unfolded Protein Binding Negative Regulation Of Phosphorylation Carbohydrate Derivative Biosynthetic Process Cellular Response To Cell-matrix Adhesion Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Oncogene-induced Cell Senescence Stress-induced Premature Senescence Negative Regulation Of Protein Metabolic Process Response To Heparin Embryonic Skeletal Joint Development Protein Glycosylation Limb Joint Morphogenesis Glycosylation Macromolecule Glycosylation Heparin Proteoglycan Biosynthetic Process Chondrocyte Hypertrophy Endochondral Bone Morphogenesis Hematopoietic Stem Cell Migration To Bone Marrow Prefoldin Complex Thymidine Metabolic Process Thymidine Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Intrinsic Apoptotic Signaling Pathway
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