EXT2 and EXT1

Number of citations of the paper that reports this interaction (PubMedID 10639137)
34

Data Source:
HPRD (in vitro, in vivo)

		EXT2	EXT1
Description		exostosin glycosyltransferase 2	exostosin glycosyltransferase 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane UDP-N-acetylglucosamine Transferase Complex Extracellular Exosome Catalytic Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Organelle Membrane Synapse Catalytic Complex
	Molecular Function	Protein Binding Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity	Protein Binding Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity
	Biological Process	Polysaccharide Biosynthetic Process Ossification Mesoderm Formation Chondrocyte Differentiation Glycosaminoglycan Biosynthetic Process Protein Glycosylation Protein N-linked Glycosylation Regulation Of Blood Pressure Gene Expression Heparan Sulfate Proteoglycan Biosynthetic Process Heparin Proteoglycan Biosynthetic Process Fluid Transport Vasodilation Cellular Response To Fibroblast Growth Factor Stimulus Multicellular Organismal-level Water Homeostasis Sulfation Sodium Ion Homeostasis Heart Contraction Endochondral Bone Morphogenesis	Polysaccharide Biosynthetic Process Cell Morphogenesis Ossification Endochondral Ossification Blood Vessel Remodeling Chondrocyte Differentiation Glandular Epithelial Cell Differentiation Hematopoietic Progenitor Cell Differentiation Hypersensitivity Heart Field Specification Chondrocyte Hypertrophy Endochondral Bone Growth Glycosaminoglycan Biosynthetic Process Protein Glycosylation Vacuole Organization Cell Adhesion Cell Surface Receptor Signaling Pathway Smoothened Signaling Pathway Gastrulation Axon Guidance Brain Development Endoderm Development Mesoderm Development Regulation Of Blood Pressure Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Virus Response To Light Intensity Gene Expression Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neural Crest Cell Differentiation Heparan Sulfate Proteoglycan Biosynthetic Process Stem Cell Division Antigen Processing And Presentation Optic Nerve Development Olfactory Bulb Development Hair Cycle Process Protein Catabolic Process Proteoglycan Biosynthetic Process Collagen Fibril Organization Heparin Proteoglycan Metabolic Process Heparin Proteoglycan Biosynthetic Process BMP Signaling Pathway Hair Follicle Morphogenesis Neuron Projection Development Glomerular Basement Membrane Development Cell Adhesion Mediated By Integrin Social Behavior Synaptic Transmission, Glutamatergic Multicellular Organism Growth Chondrocyte Proliferation Limb Joint Morphogenesis Dendritic Cell Migration Lymphocyte Adhesion To Endothelial Cell Of High Endothelial Venule Fluid Transport Wound Healing Vasodilation Fear Response Ossification Involved In Bone Maturation Cellular Response To Fibroblast Growth Factor Stimulus Cell Fate Commitment Bone Resorption Embryonic Morphogenesis Sebaceous Gland Development Chondroitin Sulfate Proteoglycan Metabolic Process Multicellular Organismal-level Water Homeostasis Leukocyte Tethering Or Rolling Sulfation Sodium Ion Homeostasis Heart Contraction Canonical Wnt Signaling Pathway Hematopoietic Stem Cell Differentiation Bone Morphogenesis Endochondral Bone Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Epithelium Development Epithelial Tube Branching Involved In Lung Morphogenesis Mesenchyme Development Smoothened Signaling Pathway Involved In Lung Development Developmental Growth Involved In Morphogenesis Sweat Gland Development Hematopoietic Stem Cell Homeostasis Motor Behavior Perichondral Bone Morphogenesis Stomach Development Protein-containing Complex Assembly Dendrite Self-avoidance Response To Growth Factor Response To Heparin Vocalization Behavior Basement Membrane Organization Cellular Response To BMP Stimulus Podocyte Differentiation Embryonic Skeletal Joint Development Lymphocyte Migration Into Lymphoid Organs Hematopoietic Stem Cell Migration To Bone Marrow Cellular Response To Virus Bone Growth Tight Junction Organization Mesenchymal Cell Differentiation Involved In Bone Development Cranial Skeletal System Development Response To Leukemia Inhibitory Factor
Pathways		HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS	HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Drugs
Diseases		Multiple exostoses Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses	Multiple exostoses Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Refractive error ( 32231278)	Adult body size ( 32376654) Autism spectrum disorder ( 28540026) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Depression in smokers ( 30219690) Endometrial cancer (Non-endometrioid histology) ( 30093612) Facial attractiveness (female raters) ( 30946739) General cognitive ability ( 29844566) Height ( 19893584) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Urate levels in obese individuals ( 25811787) White blood cell count (basophil) ( 29403010)
Interacting Genes		10 interacting genes: ANXA7 CDKN1A EXT1 GALNT5 GSKIP PFDN1 SMN1 TK1 TRAP1 UBC	6 interacting genes: EXT2 FBXW7 GOLPH3 GOLPH3L NOTCH1 TRAP1
Entrez ID		2132	2131
HPRD ID		00599	00598
Ensembl ID		ENSG00000151348	ENSG00000182197
Uniprot IDs		Q93063	Q16394
PDB IDs		7SCH 7SCJ 7SCK 7UQX 7UQY 7ZAY	7SCH 7SCJ 7SCK 7UQX 7UQY 7ZAY
Enriched GO Terms of Interacting Partners?		Glycosaminoglycan Biosynthetic Process Negative Regulation Of Kinase Activity Protein Kinase Inhibitor Activity PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Wound Healing Negative Regulation Of Protein Kinase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Lymphocyte Adhesion To Endothelial Cell Of High Endothelial Venule Glycosaminoglycan Metabolic Process Mesenchymal Cell Differentiation Involved In Bone Development Stomach Development Perichondral Bone Morphogenesis Sweat Gland Development Smoothened Signaling Pathway Involved In Lung Development Heparan Sulfate N-acetylglucosaminyltransferase Activity Thymidine Kinase Activity Translational Attenuation Epithelial Cell Differentiation Negative Regulation Of Protein Phosphorylation Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity DNA Synthesis Involved In Mitotic DNA Replication Kinase Regulator Activity Protein Kinase Binding Protein O-linked Glycosylation Unfolded Protein Binding Negative Regulation Of Phosphorylation Carbohydrate Derivative Biosynthetic Process Cellular Response To Cell-matrix Adhesion Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Oncogene-induced Cell Senescence Stress-induced Premature Senescence Negative Regulation Of Protein Metabolic Process Response To Heparin Embryonic Skeletal Joint Development Protein Glycosylation Limb Joint Morphogenesis Glycosylation Macromolecule Glycosylation Heparin Proteoglycan Biosynthetic Process Chondrocyte Hypertrophy Endochondral Bone Morphogenesis Hematopoietic Stem Cell Migration To Bone Marrow Prefoldin Complex Thymidine Metabolic Process Thymidine Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Intrinsic Apoptotic Signaling Pathway	Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Golgi Membrane Phosphatidylinositol-4-phosphate Binding Golgi To Plasma Membrane Protein Transport Vesicle Budding From Membrane Gene Expression Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Positive Regulation Of Establishment Of Protein Localization Establishment Of Protein Localization To Organelle Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Mitochondrial Intermembrane Space N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity UDP-N-acetylglucosamine Transferase Complex Heparan Sulfate N-acetylglucosaminyltransferase Activity MAML1-RBP-Jkappa- ICN1 Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Vasculogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Notch Signaling Pathway Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Distal Tubule Development Negative Regulation Of Epithelial Cell Proliferation Auditory Receptor Cell Fate Commitment Notch Signaling Involved In Heart Development Regulation Of Aorta Morphogenesis Growth Involved In Heart Morphogenesis Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Epidermal Cell Fate Specification Endocardium Morphogenesis Retinal Cone Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Pro-B Cell Differentiation Cardiac Right Ventricle Formation Glomerular Mesangial Cell Development Regulation Of Apoptotic Process Cell Migration Involved In Endocardial Cushion Formation Chemical Synaptic Transmission, Postsynaptic Compartment Pattern Specification Mitral Valve Formation
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