CDT1

Description		chromatin licensing and DNA replication factor 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nuclear Body
	Molecular Function	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding
	Biological Process	DNA Replication Checkpoint Signaling Mitotic Cell Cycle DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore DNA Replication Preinitiation Complex Assembly Response To Sorbitol Negative Regulation Of DNA-templated DNA Replication Positive Regulation Of DNA-templated DNA Replication
Pathways		Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state G1/S-Specific Transcription
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 20139978 28017375 29403010) Mean corpuscular volume ( 29403010)
Novel Interacting Genes		28 novel interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 COL6A3 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB
Interacting Genes		28 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 COL6A3 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB
Entrez ID		81620
HPRD ID		06900
Ensembl ID		ENSG00000167513
Uniprot IDs		Q9H211
PDB IDs		2LE8 2WVR 6QCG 8RWV 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Nucleoplasm Regulation Of DNA Replication DNA Damage Response Cellular Response To Stress DNA Replication DNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Macromolecule Metabolic Process Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Catabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cell Cycle G2/M Phase Transition DNA Replication Initiation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Positive Regulation Of Cell Cycle Post-translational Protein Modification Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Repair Regulation Of Primary Metabolic Process Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Regulation Of Organelle Organization Chromosome, Telomeric Region Response To Stress Mitotic G2/M Transition Checkpoint Cell Division Chromatin Binding Anaphase-promoting Complex
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