ANAPC2 and ANAPC11

Number of citations of the paper that reports this interaction (PubMedID 11739784)
57

Data Source:
HPRD (in vivo)

		ANAPC2	ANAPC11
Description		anaphase promoting complex subunit 2	anaphase promoting complex subunit 11
Image
GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol Cullin-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Anaphase-promoting Complex Nucleolus Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Nervous System Development Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression Protein Ubiquitination Cell Differentiation Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Synaptic Plasticity Positive Regulation Of Axon Extension Positive Regulation Of Dendrite Morphogenesis Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Synapse Maturation Protein Branched Polyubiquitination	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494)
Interacting Genes		17 interacting genes: ANAPC11 ANAPC7 CDC20 CDC26 CDC27 FZR1 MAD2L1 MEOX1 PTTG1 SMAD2 SUMO2 UBC UBE2C UBE2D2 UFD1 USP16 WDR5	58 interacting genes: ANAPC10 ANAPC2 BANP BEND2 CAPN11 CCNB1 CDC16 CDC20 CREB5 CRYBA2 CUL5 CYSRT1 DTX2 EFEMP1 EFEMP2 FBXO5 FOXO3 FRS3 FZR1 GPANK1 H2AC4 H2BC3 H3C1 HSD3B7 IQUB KRTAP11-1 KRTAP13-2 KRTAP19-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 MAK MGAT5B MLKL NKD2 OXER1 P4HA3 PRKAA2 PRKAB2 PTTG1 RBPMS RNF111 SPMIP9 TCEANC TLE5 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L1 UBE2S UBE2U WWOX ZAP70
Entrez ID		29882	51529
HPRD ID		07367	12452
Ensembl ID		ENSG00000176248	ENSG00000141552
Uniprot IDs		Q9UJX6	Q9NYG5
PDB IDs		4UI9 4YII 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6NXK 6OB1 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	2MT5 4R2Y 4UI9 5A31 5G04 5G05 5JG6 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Protein K11-linked Ubiquitination Cell Division Post-translational Protein Modification Modification-dependent Protein Catabolic Process Regulation Of Meiotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Sister Chromatid Segregation Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Ubiquitination Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Segregation Protein Branched Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Regulation Of Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation Protein Polyubiquitination Proteasomal Protein Catabolic Process Macromolecule Catabolic Process Regulation Of Chromosome Separation Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Regulation Of Reproductive Process Positive Regulation Of Ubiquitin Protein Ligase Activity Nucleoplasm Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Chromosome Separation Protein Modification Process Protein Catabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Nucleus Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Phase Transition Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process	Protein Polyubiquitination Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein Modification By Small Protein Conjugation Anaphase-promoting Complex Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Protein Modification Process Positive Regulation Of Ubiquitin Protein Ligase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex Binding Regulation Of Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Cell Cycle Proteasomal Protein Catabolic Process Intermediate Filament Macromolecule Catabolic Process Proteolysis Free Ubiquitin Chain Polymerization Regulation Of Sister Chromatid Segregation Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Sister Chromatid Separation Ubiquitin-protein Transferase Activity Cell Division Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Regulation Of Chromosome Segregation Regulation Of Chromosome Separation Protein Catabolic Process Regulation Of Nuclear Division Protein Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Metaphase/anaphase Transition Cytosol Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Branched Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of Reproductive Process Positive Regulation Of Cell Cycle Phase Transition SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation
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