TIMMDC1 and ORMDL1

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		TIMMDC1	ORMDL1
Description		translocase of inner mitochondrial membrane domain containing 1	ORMDL sphingolipid biosynthesis regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process
Pathways		Complex I biogenesis	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 31672989)	Bilirubin levels ( 20639394) Ferritin levels ( 25162662)
Interacting Genes		82 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL2 APOL3 APP ARL6IP6 ARLN ATP6AP2 BCAP31 C14orf180 C3orf52 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYB561D2 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 IGFBP5 KIR2DL4 LHFPL5 MARCHF5 NDUFB11 NINJ1 ORMDL1 ORMDL2 PEX16 PEX5 PIGF PTPN1 PTPRN REEP6 RNF24 SCAMP5 SCD SERF1A SERF1B SERP1 SERP2 SLC35E4 SLC35F6 SLC61A1 SLC71A2 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UBIAD1 UNC50 UNC93A VAPB VMA12 YIF1A YIPF1 YIPF4	42 interacting genes: APP AQP6 ARL13B ASGR2 BIK CD79A COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 FAM209A GPR152 HSD17B11 KCNK4 LMNA LNX1 MTIF3 PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35H1 SLC71A2 STOM TIMMDC1 TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27
Entrez ID		51300	94101
HPRD ID		12817	15092
Ensembl ID		ENSG00000113845	ENSG00000128699
Uniprot IDs		C9JU35 Q9NPL8	Q9P0S3
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipoprotein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Golgi Membrane Response To Unfolded Protein Very-low-density Lipoprotein Particle Golgi Apparatus Response To Endoplasmic Reticulum Stress High-density Lipoprotein Particle Chemical Homeostasis Intermediate-density Lipoprotein Particle Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Amyloid Fibril Formation Protein Import Into Peroxisome Membrane Negative Regulation Of Sphingolipid Biosynthetic Process Menaquinone Metabolic Process Synaptic Vesicle Membrane Serine Palmitoyltransferase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment	Membrane Endoplasmic Reticulum Protein Binding Bile Acid:sodium Symporter Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane
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