ORMDL1 and TMEM35A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ORMDL1	TMEM35A
Description		ORMDL sphingolipid biosynthesis regulator 1	transmembrane protein 35A
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex	Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Protein Binding Acetylcholine Receptor Regulator Activity
	Biological Process	Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process	Chaperone-mediated Protein Complex Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Bilirubin levels ( 20639394) Ferritin levels ( 25162662)
Interacting Genes		42 interacting genes: APP AQP6 ARL13B ASGR2 BIK CD79A COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 FAM209A GPR152 HSD17B11 KCNK4 LMNA LNX1 MTIF3 PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35H1 SLC71A2 STOM TIMMDC1 TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27	32 interacting genes: ADIPOQ APP BET1 C16orf92 CMTM5 COX20 CTSA CXCL16 CYB5B EHHADH FXYD6 GIMAP1 GOSR2 LNPEP MGLL ORMDL1 RTP2 RUSF1 THBD TMEM106C TMEM120A TMEM14C TMEM201 TMEM222 TMEM229B TMEM243 TMEM42 TRIM55 TRIM63 VAMP1 VAMP3 VAPA
Entrez ID		94101	59353
HPRD ID		15092	06523
Ensembl ID		ENSG00000128699	ENSG00000126950
Uniprot IDs		Q9P0S3	Q53FP2
PDB IDs			9H9E
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Protein Binding Bile Acid:sodium Symporter Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane	Membrane Membrane Fusion SNAP Receptor Activity SNARE Complex Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Membrane Organization Sphingomyelin Biosynthetic Process SNARE Complex Assembly Cellular Localization Endoplasmic Reticulum Vesicle Organization Positive Regulation Of CAMP/PKA Signal Transduction Response To CAMP Endoplasmic Reticulum Membrane Sphingomyelin Metabolic Process
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