TIMMDC1 and STX6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TIMMDC1	STX6
Description		translocase of inner mitochondrial membrane domain containing 1	syntaxin 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane	Golgi Membrane Nucleoplasm Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Clathrin-coated Vesicle Synaptic Vesicle Membrane Organelle Membrane SNARE Complex Vesicle Trans-Golgi Network Membrane Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Intracellular Protein Transport Vesicle Fusion Endosome Organization Protein Transport Synaptic Vesicle To Endosome Fusion Vesicle-mediated Transport Endocytic Recycling Regulation Of Protein Localization Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Vesicle Docking
Pathways		Complex I biogenesis	Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 31672989)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Creutzfeldt-Jakob disease (sporadic) ( 32949544) Intralaminar thalamic nuclei volume ( 34006833) Menopause (age at onset) ( 26414677) Progressive supranuclear palsy ( 21685912 30089514) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		82 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL2 APOL3 APP ARL6IP6 ARLN ATP6AP2 BCAP31 C14orf180 C3orf52 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYB561D2 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 IGFBP5 KIR2DL4 LHFPL5 MARCHF5 NDUFB11 NINJ1 ORMDL1 ORMDL2 PEX16 PEX5 PIGF PTPN1 PTPRN REEP6 RNF24 SCAMP5 SCD SERF1A SERF1B SERP1 SERP2 SLC35E4 SLC35F6 SLC61A1 SLC71A2 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UBIAD1 UNC50 UNC93A VAPB VMA12 YIF1A YIPF1 YIPF4	33 interacting genes: AQP6 ARMC8 DNAJC5 EBP EEA1 FAM210B GOLM2 GOPC LIME1 LMNA MARCHF2 MEOX2 MMGT1 MTERF2 MTIF3 NAPB PSMA3 PTPN9 SCN3B SNAP23 SNAP29 STOM STX16 STX1A STX2 STX7 TIMMDC1 TMEM14B TMEM205 TMEM86B VAMP4 VPS11 VPS18
Entrez ID		51300	10228
HPRD ID		12817	07231
Ensembl ID		ENSG00000113845	ENSG00000135823
Uniprot IDs		C9JU35 Q9NPL8	O43752
PDB IDs			2NPS 4J2C
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipoprotein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Golgi Membrane Response To Unfolded Protein Very-low-density Lipoprotein Particle Golgi Apparatus Response To Endoplasmic Reticulum Stress High-density Lipoprotein Particle Chemical Homeostasis Intermediate-density Lipoprotein Particle Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Amyloid Fibril Formation Protein Import Into Peroxisome Membrane Negative Regulation Of Sphingolipid Biosynthetic Process Menaquinone Metabolic Process Synaptic Vesicle Membrane Serine Palmitoyltransferase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment	Organelle Fusion Vesicle Fusion Organelle Membrane Fusion SNARE Complex Syntaxin Binding Membrane Fusion SNAP Receptor Activity Organelle Localization By Membrane Tethering Vesicle Organization Membrane Docking Vesicle Docking Vesicle-mediated Transport Membrane Organization Cytoplasmic Vesicle Establishment Of Protein Localization Protein Transport Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Organelle Localization Cellular Localization Establishment Of Localization In Cell Synaptic Vesicle Membrane Organization Membrane SNARE Binding Intracellular Transport Synaptic Vesicle To Endosome Fusion Intracellular Protein Localization Endosome Organization Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Exocytosis Localization Within Membrane Vesicle Docking Involved In Exocytosis Lysosomal Membrane ATP-dependent Protein Binding Chloride Channel Inhibitor Activity CORVET Complex Azurophil Granule Membrane Endomembrane System Regulation Of Synaptic Vesicle Priming Azurophil Granule SNARE Complex Assembly Regulation Of Protein Localization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway HOPS Complex Endocytic Vesicle Early Endosome Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Vesicle Targeting
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