TBC1D7 and ALOX5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D7	ALOX5
Description		TBC1 domain family member 7	arachidonate 5-lipoxygenase
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cytoplasmic Vesicle TSC1-TSC2 Complex Ciliary Basal Body	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Ficolin-1-rich Granule Lumen
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding TSC1-TSC2 Complex Binding	Arachidonate 5-lipoxygenase Activity Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Arachidonate 8(S)-lipoxygenase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Cellular Response To Starvation Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of GTPase Activity Response To Growth Factor Activation Of GTPase Activity Negative Regulation Of Cilium Assembly Negative Regulation Of TORC1 Signaling	Long-chain Fatty Acid Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Lipid Metabolic Process Icosanoid Metabolic Process Leukotriene Metabolic Process Response To Stress Inflammatory Response Humoral Immune Response Negative Regulation Of Angiogenesis Arachidonate Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Bone Mineralization Lipid Oxidation Dendritic Cell Migration Glucose Homeostasis Long-chain Fatty Acid Biosynthetic Process Regulation Of Fat Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Regulation Of Inflammatory Response To Wounding Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Leukotriene A4 Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Lipoxin Biosynthetic Process
Pathways		TBC/RABGAPs	Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Drugs			Icosapent Vitamin E Masoprocol Aminosalicylic acid Mesalazine Montelukast Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Morniflumate Diacerein Fostamatinib Rhein alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Migraine ( 23793025) Migraine without aura ( 23793025)	Alanine aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 20139978 32888494) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)
Interacting Genes		30 interacting genes: AKT1 ALOX5 APP BAG4 BLZF1 GABARAPL1 HOOK1 IKBKG INCA1 KEAP1 KRT19 KRT35 LDOC1 LNX2 LZTS1 LZTS2 MAP1LC3A MIPOL1 MMADHC NEDD4 NEDD4L PICK1 RPGRIP1 SH3GLB2 SSNA1 TRAF4 TRIM62 TSC1 XPA YWHAZ	27 interacting genes: ACTB ALOX5AP ALPL APP C10orf67 CCDC174 CEP57L1 CEP63 COTL1 DICER1 GATC GRB2 HHIPL2 HSD17B1 LCN1 LTC4S MAD1L1 MAPKAPK2 MEOX1 MEOX2 MTDH NUTM1 OOEP REL SYCE1 TBC1D7 TGFBRAP1
Entrez ID		51256	240
HPRD ID		18165	01065
Ensembl ID		ENSG00000145979	ENSG00000012779
Uniprot IDs		Q9P0N9 U3KPY5	P09917
PDB IDs		3QWL 4Z6Y 5EJC 5ULO 7DL2 9CE3	3O8Y 3V92 3V98 3V99 6N2W 6NCF 7TTJ 7TTK 7TTL
Enriched GO Terms of Interacting Partners?		Cytosol Cellular Response To Starvation Identical Protein Binding Ubiquitin Protein Ligase Binding Response To Starvation Regulation Of Autophagy Cellular Response To Nutrient Levels Regulation Of Synapse Organization Cytoplasm Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macroautophagy Negative Regulation Of Protein Localization Protein Domain Specific Binding Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Protein Localization To Nucleus Sodium Channel Inhibitor Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Maternal Placenta Development Cellular Response To Decreased Oxygen Levels Protein Polyubiquitination Regulation Of Protein Localization Cytoskeleton Potassium Channel Inhibitor Activity Cellular Response To Nitrogen Starvation Regulation Of Protein Localization To Nucleus Cellular Response To Oxygen Levels Response To Nutrient Levels Nuclear Envelope Lumen Anoikis TORC1 Signaling Protein Localization To Membrane Regulation Of Dendrite Morphogenesis Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of TORC1 Signaling Cellular Response To Stress Regulation Of Sodium Ion Transport Vacuole Organization Negative Regulation Of Sodium Ion Transport Phosphatidylethanolamine Binding Positive Regulation Of Catabolic Process Response To Stress Positive Regulation Of Fibroblast Migration Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis TOR Signaling Regulation Of Protein Catabolic Process Cell Projection Organization	Leukotriene Metabolic Process Leukotriene-C4 Synthase Activity Somite Specification Embryonic Pattern Specification
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