TBC1D7 and MMADHC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D7	MMADHC
Description		TBC1 domain family member 7	metabolism of cobalamin associated D
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cytoplasmic Vesicle TSC1-TSC2 Complex Ciliary Basal Body	Cytoplasm Mitochondrion Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding TSC1-TSC2 Complex Binding	Protein Binding Molecular Carrier Activity
	Biological Process	Cellular Response To Starvation Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of GTPase Activity Response To Growth Factor Activation Of GTPase Activity Negative Regulation Of Cilium Assembly Negative Regulation Of TORC1 Signaling	Cobalamin Metabolic Process
Pathways		TBC/RABGAPs	Defective MMADHC causes MMAHCD Cobalamin (Cbl) metabolism
Drugs
Diseases			Methylmalonic aciduria (MMA)
GWAS		Migraine ( 23793025) Migraine without aura ( 23793025)	Daytime sleep phenotypes ( 27126917) Liver enzyme levels (alanine transaminase) ( 24124411) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095)
Interacting Genes		30 interacting genes: AKT1 ALOX5 APP BAG4 BLZF1 GABARAPL1 HOOK1 IKBKG INCA1 KEAP1 KRT19 KRT35 LDOC1 LNX2 LZTS1 LZTS2 MAP1LC3A MIPOL1 MMADHC NEDD4 NEDD4L PICK1 RPGRIP1 SH3GLB2 SSNA1 TRAF4 TRIM62 TSC1 XPA YWHAZ	7 interacting genes: CINP CREB5 EPC2 MMACHC POU4F2 PRNP TBC1D7
Entrez ID		51256	27249
HPRD ID		18165	10781
Ensembl ID		ENSG00000145979	ENSG00000168288
Uniprot IDs		Q9P0N9 U3KPY5	Q9H3L0
PDB IDs		3QWL 4Z6Y 5EJC 5ULO 7DL2 9CE3	5CUZ 5CV0 6X8Z
Enriched GO Terms of Interacting Partners?		Cytosol Cellular Response To Starvation Identical Protein Binding Ubiquitin Protein Ligase Binding Response To Starvation Regulation Of Autophagy Cellular Response To Nutrient Levels Regulation Of Synapse Organization Cytoplasm Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Negative Regulation Of Macroautophagy Negative Regulation Of Protein Localization Protein Domain Specific Binding Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Protein Localization To Nucleus Sodium Channel Inhibitor Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Maternal Placenta Development Cellular Response To Decreased Oxygen Levels Protein Polyubiquitination Regulation Of Protein Localization Cytoskeleton Potassium Channel Inhibitor Activity Cellular Response To Nitrogen Starvation Regulation Of Protein Localization To Nucleus Cellular Response To Oxygen Levels Response To Nutrient Levels Nuclear Envelope Lumen Anoikis TORC1 Signaling Protein Localization To Membrane Regulation Of Dendrite Morphogenesis Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of TORC1 Signaling Cellular Response To Stress Regulation Of Sodium Ion Transport Vacuole Organization Negative Regulation Of Sodium Ion Transport Phosphatidylethanolamine Binding Positive Regulation Of Catabolic Process Response To Stress Positive Regulation Of Fibroblast Migration Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis TOR Signaling Regulation Of Protein Catabolic Process Cell Projection Organization
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