ALOX5 and ALPL

Number of citations of the paper that reports this interaction (PubMedID 26210919)
0

Data Source:
BioGRID (enzymatic study)

		ALOX5	ALPL
Description		arachidonate 5-lipoxygenase	alkaline phosphatase, biomineralization associated
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Intermembrane Space Plasma Membrane Membrane Extracellular Matrix Mitochondrial Membrane Extracellular Membrane-bounded Organelle Extracellular Exosome Side Of Membrane
	Molecular Function	Arachidonate 5-lipoxygenase Activity Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Arachidonate 8(S)-lipoxygenase Activity Metal Ion Binding Dioxygenase Activity	Alkaline Phosphatase Activity Inorganic Diphosphate Phosphatase Activity Calcium Ion Binding Pyrophosphatase Activity Hydrolase Activity Phosphatase Activity ATP Hydrolysis Activity Pyridoxal Phosphatase Activity ADP Phosphatase Activity Metal Ion Binding Phosphoamidase Activity Phosphoethanolamine Phosphatase Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Lipid Metabolic Process Icosanoid Metabolic Process Leukotriene Metabolic Process Response To Stress Inflammatory Response Humoral Immune Response Negative Regulation Of Angiogenesis Arachidonate Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Bone Mineralization Lipid Oxidation Dendritic Cell Migration Glucose Homeostasis Long-chain Fatty Acid Biosynthetic Process Regulation Of Fat Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Regulation Of Inflammatory Response To Wounding Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Leukotriene A4 Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Lipoxin Biosynthetic Process	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Developmental Process Involved In Reproduction Cellular Homeostasis Bone Mineralization Biomineral Tissue Development Response To Lipopolysaccharide Response To Insulin Response To Vitamin D Response To Vitamin B6 Response To Macrophage Colony-stimulating Factor Pyridoxal Phosphate Metabolic Process Response To Antibiotic Response To Glucocorticoid Phosphate Ion Homeostasis Calcium Ion Homeostasis Cementum Mineralization Positive Regulation Of Cold-induced Thermogenesis Futile Creatine Cycle Inhibition Of Non-skeletal Tissue Mineralization Response To Sodium Phosphate
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Icosapent Vitamin E Masoprocol Aminosalicylic acid Mesalazine Montelukast Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Morniflumate Diacerein Fostamatinib Rhein alpha-Tocopherol succinate D-alpha-Tocopherol acetate	Mersalyl
Diseases			Hypophosphatasia
GWAS		Alanine aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 20139978 32888494) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)	Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) B6 vitamer levels (multivariate analysis) ( 30583557) Calcific aortic valve stenosis ( 32141789) Folate pathway vitamin levels ( 19303062 19744961) Heel bone mineral density ( 30598549) Hematological and biochemical traits ( 20139978) Kidney stones ( 31729369 26272126) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Phosphorus levels ( 29403010 20558539) Plasma pyridoxal phosphate to pyridoxal ratio ( 31641590) Pyridoxal 5'-phosphate levels ( 25972531 31641590) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urolithiasis ( 30975718) Vitamin B levels in ischemic stroke ( 25147783)
Interacting Genes		27 interacting genes: ACTB ALOX5AP ALPL APP C10orf67 CCDC174 CEP57L1 CEP63 COTL1 DICER1 GATC GRB2 HHIPL2 HSD17B1 LCN1 LTC4S MAD1L1 MAPKAPK2 MEOX1 MEOX2 MTDH NUTM1 OOEP REL SYCE1 TBC1D7 TGFBRAP1	8 interacting genes: ALOX5 EEF1A1 LCOR MAP3K14 PCSK6 SRPK2 TRAF2 TRAF3
Entrez ID		240	249
HPRD ID		01065	01377
Ensembl ID		ENSG00000012779	ENSG00000162551
Uniprot IDs		P09917	P05186
PDB IDs		3O8Y 3V92 3V98 3V99 6N2W 6NCF 7TTJ 7TTK 7TTL	7YIV 7YIW 7YIX
Enriched GO Terms of Interacting Partners?		Leukotriene Metabolic Process Leukotriene-C4 Synthase Activity Somite Specification Embryonic Pattern Specification	Thioesterase Binding CD40 Receptor Complex Immune Response Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Defense Response Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Immune System Process Protein Kinase Binding Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo TORC2 Complex Disassembly Protein Phosphatase Binding Tumor Necrosis Factor-mediated Signaling Pathway TRAF2-GSTP1 Complex Signaling Adaptor Activity TORC1 Complex Assembly CD40 Receptor Binding Response To Other Organism Ubiquitin Ligase Complex Cytoplasmic Side Of Plasma Membrane Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Ficolin-1-rich Granule Lumen Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Secretory Granule Lumen Arachidonate Metabolite Production Involved In Inflammatory Response Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Eukaryotic Translation Elongation Factor 1 Complex Response To External Biotic Stimulus Nuclear Speck Organization Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Nerve Growth Factor Binding CD27 Signaling Pathway Innate Immune Response Negative Regulation Of Vascular Wound Healing Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Toll Signaling Pathway Leukocyte Chemotaxis Involved In Inflammatory Response Regulation Of Chaperone-mediated Autophagy
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?