RNF181 and CLK4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RNF181	CLK4
Description		ring finger protein 181	CDC like kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Ubiquitination Protein Autoubiquitination	Regulation Of RNA Splicing
Pathways		E3 ubiquitin ligases ubiquitinate target proteins
Drugs			Fostamatinib
Diseases
GWAS		Prostate cancer ( 21743467)	Urate levels in obese individuals ( 25811787)
Interacting Genes		32 interacting genes: ALB BCL10 BIRC2 BTG1 CARD11 CLK4 ELL2 FGB HBA1 MCM7 MRPS6 MT1E MT1H NDUFB10 NPY5R PEG10 RBCK1 RPL5 SFMBT2 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U VPS11 ZMYND10	15 interacting genes: CLASRP HSPB2 KPNA1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 MITF RNF181 SRPK1 SRRM4 SRSF1 SRSF10 UBL5
Entrez ID		51255	57396
HPRD ID		14236	12140
Ensembl ID		ENSG00000168894	ENSG00000113240
Uniprot IDs		Q9P0P0	Q9HAZ1
PDB IDs			6FYV
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein K48-linked Ubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Metabolic Process Protein Monoubiquitination Positive Regulation Of Protein Polyubiquitination Proteolysis Transferase Activity Protein K63-linked Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Catabolic Process Regulation Of Protein Polyubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination CBM Complex Positive Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Post-translational Protein Modification Protein Catabolic Process Regulation Of Intracellular Signal Transduction ATP Binding Transcription Coactivator Activity Canonical NF-kappaB Signal Transduction Nucleotide Binding Macromolecule Metabolic Process Proteasomal Protein Catabolic Process TORC1 Signaling Detoxification Of Copper Ion Nucleus Regulation Of Protein K63-linked Ubiquitination CARD Domain Binding Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex TOR Signaling Regulation Of Signal Transduction	Keratin Filament Intermediate Filament RNA Splicing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Metabolic Process RS Domain Binding Regulation Of RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome MRNA Binding Melanocyte Apoptotic Process Protein Localization To P-body Satellite Cell Activation Involved In Skeletal Muscle Regeneration Somatic Muscle Development Negative Regulation Of MRNA Metabolic Process DNA Topoisomerase Binding
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