CLK4 and CLASRP

Number of citations of the paper that reports this interaction (PubMedID 12169693)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CLK4	CLASRP
Description		CDC like kinase 4	CLK4 associating serine/arginine rich protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Regulation Of RNA Splicing	MRNA Processing RNA Splicing
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Urate levels in obese individuals ( 25811787)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: CLASRP HSPB2 KPNA1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 MITF RNF181 SRPK1 SRRM4 SRSF1 SRSF10 UBL5	14 interacting genes: APP ATXN1 CDK6 CLK1 CLK2 CLK3 CLK4 DAB1 DAZAP2 DYRK1A RHOXF2 SMAD3 SRPK2 VDR
Entrez ID		57396	11129
HPRD ID		12140	11552
Ensembl ID		ENSG00000113240	ENSG00000104859
Uniprot IDs		Q9HAZ1	Q8N2M8
PDB IDs		6FYV
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament RNA Splicing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Metabolic Process RS Domain Binding Regulation Of RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome MRNA Binding Melanocyte Apoptotic Process Protein Localization To P-body Satellite Cell Activation Involved In Skeletal Muscle Regeneration Somatic Muscle Development Negative Regulation Of MRNA Metabolic Process DNA Topoisomerase Binding	Protein Serine/threonine/tyrosine Kinase Activity Protein Serine Kinase Activity Regulation Of RNA Splicing Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nuclear Speck Positive Regulation Of Gene Expression Identical Protein Binding Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Adult Locomotory Behavior ATP Binding Positive Regulation Of Biosynthetic Process Protein Phosphorylation Protein Serine/threonine Kinase Binding Positive Regulation Of Macromolecule Metabolic Process Nucleotide Binding Transferase Activity Phosphorylation Negative Regulation Of MiRNA Transcription Adult Behavior Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Locomotory Behavior Negative Regulation Of RNA Metabolic Process Receptor Complex Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Bone Mineralization Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Dendrite Development Cyclin D2-CDK6 Complex Non-membrane Spanning Protein Tyrosine Kinase Activity Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration
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