CLK4 and KPNA1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CLK4	KPNA1
Description		CDC like kinase 4	karyopherin subunit alpha 1
Image
GO Annotations	Cellular Component	Nucleus	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite NLS-dependent Protein Nuclear Import Complex Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Regulation Of RNA Splicing	Regulation Of DNA Recombination Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein Transport Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of Canonical Wnt Signaling Pathway Postsynapse To Nucleus Signaling Pathway
Pathways			ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Assembly of the ORC complex at the origin of replication Interferon alpha/beta signaling Inhibition of nitric oxide production
Drugs		Fostamatinib
Diseases
GWAS		Urate levels in obese individuals ( 25811787)	Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		15 interacting genes: CLASRP HSPB2 KPNA1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 MITF RNF181 SRPK1 SRRM4 SRSF1 SRSF10 UBL5	50 interacting genes: ANP32A ANP32B ARNT ATM BCAR3 CD86 CDKN1B CENPF CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GNL3L GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP54 NUP62 OGT ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RIPK4 RUNX1T1 SENP2 SF1 SKP2 SLC25A21-AS1 SRP19 STAT1 STAT3 TAF9 UBR5
Entrez ID		57396	3836
HPRD ID		12140	02819
Ensembl ID		ENSG00000113240	ENSG00000114030
Uniprot IDs		Q9HAZ1	P52294
PDB IDs		6FYV	2JDQ 3TJ3 4B18 6WX9
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament RNA Splicing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Metabolic Process RS Domain Binding Regulation Of RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome MRNA Binding Melanocyte Apoptotic Process Protein Localization To P-body Satellite Cell Activation Involved In Skeletal Muscle Regeneration Somatic Muscle Development Negative Regulation Of MRNA Metabolic Process DNA Topoisomerase Binding	Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Protein Localization To Nucleus Regulation Of Gene Expression Import Into Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Nuclear Pore Intracellular Protein Localization Positive Regulation Of Gene Expression Regulation Of Developmental Process Hsp90 Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Oxidative Stress Establishment Of Protein Localization DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Transcription Corepressor Binding Regulation Of Erythrocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Glycolytic Process V(D)J Recombination
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