IRAK4 and TICAM2

Number of citations of the paper that reports this interaction (PubMedID 12721283)
0

Data Source:
HPRD (in vitro, in vivo)

		IRAK4	TICAM2
Description		interleukin 1 receptor associated kinase 4	TIR domain containing adaptor molecule 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Endosome Membrane Extrinsic Component Of Plasma Membrane	Phagocytic Cup Cytoplasm Endosome Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Early Endosome Membrane Late Endosome Membrane Cell Projection
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine Kinase Activity	Protein Binding Signaling Adaptor Activity Molecular Adaptor Activity
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Neutrophil Mediated Immunity MyD88-dependent Toll-like Receptor Signaling Pathway Signal Transduction JNK Cascade Toll Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Interleukin-1-mediated Signaling Pathway Neutrophil Migration	Immune System Process Phagocytosis Inflammatory Response Signal Transduction Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Response To Other Organism Cellular Response To Lipopolysaccharide Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways		PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane	Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF-mediated programmed cell death Neutrophil degranulation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Drugs		1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE Fostamatinib
Diseases		Defects of toll-like receptor signaling, including the following disease: Il-1 receptor-associated kinase 4 (IRAK-4) deficiency
GWAS		Immune reponse to smallpox (secreted TNF-alpha) ( 22610502) Inflammatory bowel disease ( 27569725)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		23 interacting genes: ARNT EIF4EBP1 ERBB3 H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 IKBKG IL36RN IRAK1 MBP MYD88 PELI1 PELI2 PELI3 TBPL1 TICAM2 TIRAP TRAF6 TRIM7 ZNF597	21 interacting genes: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 LVRN MEF2C MEOX2 NTAQ1 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6
Entrez ID		51135	353376
HPRD ID		06051	16313
Ensembl ID		ENSG00000198001	ENSG00000243414
Uniprot IDs		B2RAP9 B4E359 Q69FE3 Q9NWZ3	Q86XR7
PDB IDs		2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP 4RMZ 4U97 4U9A 4XS2 4Y73 4YO6 4YP8 4ZTL 4ZTM 4ZTN 5K72 5K75 5K76 5K7G 5K7I 5KX7 5KX8 5T1S 5T1T 5UIQ 5UIR 5UIS 5UIT 5UIU 5W84 5W85 6EG9 6EGA 6EGD 6EGE 6EGF 6F3D 6F3E 6F3G 6F3I 6LXY 6MOM 6N8G 6O8U 6O94 6O95 6O9D 6RFI 6RFJ 6THW 6THX 6THZ 6TI8 6TIA 6UYA 6VQL 7C2V 7C2W 7QG1 7QG2 7QG3 7QG5 8ATB 8ATL 8ATN 8BR5 8BR6 8BR7 8DKS 8SCE 8SCV 8SCW 8TVM 8TVN 8TX0 8UCB 8UCC 8V1O 8V2F 8V2L 8W3W 8W3X 8WTF	2M1W 9DKI 9DLG
Enriched GO Terms of Interacting Partners?		Chromosome Condensation Nucleosomal DNA Binding Negative Regulation Of DNA Recombination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA Recombination Chromatin DNA Binding Structural Constituent Of Chromatin Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Nucleosome Assembly Cell Surface Pattern Recognition Receptor Signaling Pathway Nucleosome Euchromatin Nucleosome Organization Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Toll Signaling Pathway Signaling Adaptor Activity Regulation Of Macromolecule Metabolic Process Innate Immune Response Response To Lipopolysaccharide Interleukin-33-mediated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Protein-DNA Complex Assembly Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Production Defense Response To Symbiont Defense Response To Other Organism Regulation Of Metabolic Process Regulation Of Cytokine Production Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Immune Response Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-6 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Chemokine Production Regulation Of DNA Metabolic Process Response To External Biotic Stimulus	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Immune Response-activating Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Regulation Of Defense Response Positive Regulation Of Immune Response Regulation Of Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Immune Response Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Toll Signaling Pathway Regulation Of Interferon-beta Production Endolysosomal Toll-like Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Response To External Biotic Stimulus Regulation Of Interleukin-6 Production Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Response To Other Organism Endosome Membrane Positive Regulation Of Interferon-beta Production
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