TICAM2 and OPN1LW

Number of citations of the paper that reports this interaction (PubMedID 14517278)
61

Data Source:
HPRD (in vitro)

		TICAM2	OPN1LW
Description		TIR domain containing adaptor molecule 2	opsin 1, long wave sensitive
Image
GO Annotations	Cellular Component	Phagocytic Cup Cytoplasm Endosome Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Early Endosome Membrane Late Endosome Membrane Cell Projection	Photoreceptor Outer Segment Plasma Membrane Membrane Photoreceptor Disc Membrane
	Molecular Function	Protein Binding Signaling Adaptor Activity Molecular Adaptor Activity	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Photoreceptor Activity Photoreceptor Activity
	Biological Process	Immune System Process Phagocytosis Inflammatory Response Signal Transduction Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Response To Other Organism Cellular Response To Lipopolysaccharide Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Detection Of Visible Light Absorption Of Visible Light Positive Regulation Of Cytokinesis Cellular Response To Light Stimulus
Pathways		Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF-mediated programmed cell death Neutrophil degranulation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	The retinoid cycle in cones (daylight vision) G alpha (i) signalling events Opsins Defective visual phototransduction due to OPN1LW loss of function
Drugs
Diseases			Blue cone monochromacy Colorblindness, including: Dichromacy; Anomalous trichromacy
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Response to antidepressants (symptom improvement) ( 29160301)	Lymphocyte count ( 32888494)
Interacting Genes		21 interacting genes: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 LVRN MEF2C MEOX2 NTAQ1 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6	7 interacting genes: NCOA2 NRM PIAS3 RANBP2 TAFAZZIN TICAM2 TRARG1
Entrez ID		353376	5956
HPRD ID		16313	02366
Ensembl ID		ENSG00000243414	ENSG00000102076
Uniprot IDs		Q86XR7	P04000
PDB IDs		2M1W 9DKI 9DLG	8IU2
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Immune Response-activating Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Regulation Of Defense Response Positive Regulation Of Immune Response Regulation Of Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Immune Response Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Toll Signaling Pathway Regulation Of Interferon-beta Production Endolysosomal Toll-like Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Response To External Biotic Stimulus Regulation Of Interleukin-6 Production Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Response To Other Organism Endosome Membrane Positive Regulation Of Interferon-beta Production	SUMO Ligase Activity SUMO Transferase Activity Toll-like Receptor Signaling Pathway Regulation Of Small Molecule Metabolic Process Protein Sumoylation Innate Immune Response-activating Signaling Pathway Annulate Lamellae Negative Regulation Of Immune System Process Cytoplasmic Periphery Of The Nuclear Pore Complex Pattern Recognition Receptor Signaling Pathway Negative Regulation Of RNA Export From Nucleus SUMO Ligase Complex Regulation Of Glucose Metabolic Process Nuclear Pore Cytoplasmic Filaments Regulation Of Cardiolipin Metabolic Process Cardiolipin Acyl-chain Remodeling 1-acylglycerophosphocholine O-acyltransferase Activity Positive Regulation Of Cardiolipin Metabolic Process Transcription Coregulator Activity Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Thyroglobulin Triiodothyronine Response To Thyroglobulin Triiodothyronine Glucose Import In Response To Insulin Stimulus Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production TRAM-dependent Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Nuclear Envelope RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Aryl Hydrocarbon Receptor Binding Intracellular Receptor Signaling Pathway Nuclear Pore Nuclear Basket Nuclear Inclusion Body Kinase Activator Activity Nuclear Membrane Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process Cristae Formation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Locomotor Rhythm Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Endosome To Plasma Membrane Protein Transport Vesicle Fusion To Plasma Membrane MyD88-independent Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
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